Challenges in IBD Research: Environmental Triggers.
Crohn’s disease
antibiotic
diet
environment
epidemiology
exposome
in silico modeling
pollutant
smoking
ulcerative colitis
virus
Journal
Inflammatory bowel diseases
ISSN: 1536-4844
Titre abrégé: Inflamm Bowel Dis
Pays: England
ID NLM: 9508162
Informations de publication
Date de publication:
16 05 2019
16 05 2019
Historique:
received:
29
03
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
2
6
2020
Statut:
ppublish
Résumé
Environmental triggers is part of five focus areas of the Challenges in IBD research document, which also includes preclinical human IBD mechanisms, novel technologies, precision medicine and pragmatic clinical research. The Challenges in IBD research document provides a comprehensive overview of current gaps in inflammatory bowel diseases (IBD) research and delivers actionable approaches to address them. It is the result of a multidisciplinary input from scientists, clinicians, patients, and funders, and represents a valuable resource for patient centric research prioritization. In particular, the environmental triggers section is focused on the main research gaps in elucidating causality of environmental factors in IBD. Research gaps were identified in: 1) epidemiology of exposures; 2) identification of signatures of biological response to exposures; and 3) mechanisms of how environmental exposures drive IBD. To address these gaps, the implementation of longitudinal prospective studies to determine disease evolution and identify sub-clinical changes in response to exposures is proposed. This can help define critical windows of vulnerability and risk prediction. In addition, systems biology analysis and in silico modeling were proposed as approaches to integrate the IBD exposome for the identification of biological signatures of response to exposures, and to develop prediction models of the effects of environmental factors in driving disease activity and response to therapy. This research could lead to identification of biomarkers of exposures and new modalities for therapeutic intervention. Finally, hypothesis-driven mechanistic studies to understand gene-environment interactions and to validate causality of priority factors should be performed to determine how environment influences clinical outcomes.
Identifiants
pubmed: 31095702
pii: 5490492
doi: 10.1093/ibd/izz076
pmc: PMC6787673
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S13-S23Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK048351
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Environ Health Perspect. 2014 Jun;122(6):535-44
pubmed: 24610234
Proc Nutr Soc. 2002 Feb;61(1):123-30
pubmed: 12002786
Chem Res Toxicol. 2016 Aug 15;29(8):1225-51
pubmed: 27367298
Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1075-84
pubmed: 22403795
Toxicol Ind Health. 2011 Feb;27(1):51-6
pubmed: 20826551
PLoS One. 2012;7(10):e47669
pubmed: 23118887
Bioanalysis. 2017 Jan;9(1):81-98
pubmed: 27921453
Aliment Pharmacol Ther. 2016 Jun;43(12):1300-10
pubmed: 27117843
Nature. 2014 Dec 4;516(7529):94-8
pubmed: 25409145
World J Gastroenterol. 2015 Oct 28;21(40):11371-8
pubmed: 26523104
Gut. 2019 Feb;68(2):218-225
pubmed: 29321166
Reprod Toxicol. 2017 Mar;68:85-104
pubmed: 27421580
Gut. 2004 Oct;53(10):1459-64
pubmed: 15361495
Expert Rev Clin Immunol. 2016 Oct;12(10):1091-107
pubmed: 27156530
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):39-49
pubmed: 29018271
J Crohns Colitis. 2019 Mar 30;13(4):410-416
pubmed: 30371776
Expert Rev Gastroenterol Hepatol. 2015;9(12):1523-34
pubmed: 26474349
EMBO Rep. 2013 Apr;14(4):319-27
pubmed: 23478337
Am J Gastroenterol. 2009 May;104(5):1298-313; quiz 1314
pubmed: 19337242
Science. 2012 Jun 8;336(6086):1314-7
pubmed: 22674328
Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S24-S30
pubmed: 31095703
Gastroenterology. 2001 Apr;120(5):1093-9
pubmed: 11266373
Toxicol Sci. 2016 Aug;152(2):323-39
pubmed: 27208079
World J Gastroenterol. 2017 Dec 7;23(45):8082-8089
pubmed: 29259384
Cell. 2016 Oct 6;167(2):444-456.e14
pubmed: 27716507
Science. 2016 Jan 15;351(6270):
pubmed: 26816384
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:107-127
pubmed: 30095351
Curr Opin Immunol. 2011 Dec;23(6):761-8
pubmed: 22115876
World J Gastroenterol. 2014 Apr 14;20(14):3976-85
pubmed: 24744587
Science. 2014 Aug 1;345(6196):578-82
pubmed: 25082704
MBio. 2016 Sep 20;7(5):
pubmed: 27651359
Front Public Health. 2017 Sep 27;5:208
pubmed: 29021977
Inflamm Bowel Dis. 2017 Dec 19;24(1):12-24
pubmed: 29272477
Gut. 2013 Apr;62(4):630-49
pubmed: 23335431
Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S31-S39
pubmed: 31095701
Cancer Res. 2017 Apr 15;77(8):1783-1812
pubmed: 28292977
J Pediatr. 2018 Feb;193:76-84.e6
pubmed: 29237538
Nat Biotechnol. 2017 Aug;35(8):747-756
pubmed: 28714965
J Physiol Pharmacol. 2009 Mar;60(1):107-18
pubmed: 19439813
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
J Crohns Colitis. 2014 Nov;8(11):1464-70
pubmed: 24958064
Nature. 2016 Jun 08;534(7606):191-9
pubmed: 27279212
Dig Dis Sci. 1989 Dec;34(12):1841-54
pubmed: 2598752
Inflamm Bowel Dis. 2015 Mar;21(3):656-65
pubmed: 25545379
Cell. 2016 Jun 16;165(7):1708-1720
pubmed: 27264604
Cell. 2010 Jun 25;141(7):1135-45
pubmed: 20602997
Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S40-S47
pubmed: 31095704
J Expo Sci Environ Epidemiol. 2011 Jan-Feb;21(1):5-9
pubmed: 21081972
Cell. 2015 Jan 29;160(3):447-60
pubmed: 25619688
Pharmacol Rep. 2014 Oct;66(5):766-75
pubmed: 25149979
Am J Gastroenterol. 2017 Jul;112(7):1120-1134
pubmed: 28417994
Gastroenterology. 2014 May;146(6):1564-72
pubmed: 24503132
Nature. 2018 Jan 11;553(7687):208-211
pubmed: 29323293
BMJ. 2018 Jun 13;361:bmj.k2173
pubmed: 29898881
Am J Gastroenterol. 2010 Sep;105(9):1994-2002
pubmed: 20372115
Nutrients. 2017 Feb 22;9(2):null
pubmed: 28241431
Circ Cardiovasc Genet. 2009 Dec;2(6):637-51
pubmed: 20031645
Am J Gastroenterol. 2018 Mar;113(3):405-417
pubmed: 29336432
Cochrane Database Syst Rev. 2018 Apr 01;4:CD000542
pubmed: 29607496
Inflamm Bowel Dis. 2012 Jul;18(7):1340-55
pubmed: 22069240
Autoimmun Rev. 2014 Jan;13(1):3-10
pubmed: 23774107
J Allergy (Cairo). 2012;2012:746125
pubmed: 22187573
J Cell Biochem. 2018 Jan;119(1):157-184
pubmed: 28643849
Gastroenterology. 2017 Aug;153(2):550-565
pubmed: 28506689
Genome Biol. 2012 Apr 16;13(9):R79
pubmed: 23013615
Nature. 2014 Oct 9;514(7521):181-6
pubmed: 25231862
Aliment Pharmacol Ther. 2015 Jan;41(1):3-25
pubmed: 25316115
Inflamm Bowel Dis. 2011 Aug;17(8):1784-91
pubmed: 21744434
Environ Sci Technol. 2017 Jun 6;51(11):5889-5898
pubmed: 28482653
Nat Rev Gastroenterol Hepatol. 2009 May;6(5):306-14
pubmed: 19404271
Nature. 2015 Mar 5;519(7541):92-6
pubmed: 25731162
Nat Rev Immunol. 2014 Jun;14(6):405-16
pubmed: 24854590
Diabetologia. 1992 Jul;35(7):595-601
pubmed: 1644236
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
Curr Opin Allergy Clin Immunol. 2010 Jun;10(3):238-45
pubmed: 20431371
Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S5-S12
pubmed: 31095706
Aliment Pharmacol Ther. 2016 Mar;43(5):549-61
pubmed: 26749371
Lancet. 2017 Mar 25;389(10075):1218-1228
pubmed: 28214091