OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness, and Minimum Cross-Sectional Area in Healthy Eyes.
Adult
Anatomy, Cross-Sectional
Bruch Membrane
/ anatomy & histology
Cross-Sectional Studies
Female
Healthy Volunteers
Humans
Male
Middle Aged
Nerve Fibers
Neural Tube
/ anatomy & histology
Observer Variation
Optic Disk
/ anatomy & histology
Retinal Ganglion Cells
/ cytology
Sclera
/ anatomy & histology
Tomography, Optical Coherence
Journal
American journal of ophthalmology
ISSN: 1879-1891
Titre abrégé: Am J Ophthalmol
Pays: United States
ID NLM: 0370500
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
06
02
2019
revised:
03
05
2019
accepted:
06
05
2019
pubmed:
17
5
2019
medline:
28
3
2020
entrez:
17
5
2019
Statut:
ppublish
Résumé
To assess anterior scleral canal opening (ASCO) offset relative to Bruch's membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Cross-sectional study. After optical coherence tomography optic nerve head and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented. Planes, centroids, size, and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural canal axis and the BMO plane perpendicular vector. NCMCA was defined by projecting BMO and ASCO points onto a neural canal axis perpendicular plane and measuring the area of overlap. The angular distance between superior and inferior peak RNFLT was measured, and correlations between RFNLT, BMO, ASCO, ASCO/BMO offset, and NCMCA were assessed. Mean (SD) NCMCA was significantly smaller than either the BMO or ASCO area (1.33 (0.42), 1.82 (0.38), 2.22 (0.43) mm ASCO/BMO offset underlies neural canal direction, obliqueness, and NCMCA. RNFLT is more strongly correlated to NCMCA than to BMO or ASCO, and its peripapillary distribution is influenced by neural canal direction.
Identifiants
pubmed: 31095953
pii: S0002-9394(19)30229-6
doi: 10.1016/j.ajo.2019.05.009
pmc: PMC6851461
mid: NIHMS1529583
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-205Subventions
Organisme : NEI NIH HHS
ID : R01 EY019674
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY021281
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Références
Ophthalmology. 2018 Aug;125(8):1215-1223
pubmed: 29550000
J Glaucoma. 2008 Oct-Nov;17(7):519-28
pubmed: 18854727
Invest Ophthalmol Vis Sci. 2014 Oct 09;55(11):7332-42
pubmed: 25301880
J Glaucoma. 2014 Sep;23(7):471-6
pubmed: 23970338
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5015-5021
pubmed: 28973373
Ophthalmology. 2016 Dec;123(12):2509-2518
pubmed: 27769587
PLoS One. 2014 Dec 31;9(12):e116305
pubmed: 25551632
PLoS One. 2017 Oct 12;12(10):e0186453
pubmed: 29023585
Arch Ophthalmol. 1987 Dec;105(12):1683-5
pubmed: 3689192
Am J Ophthalmol. 2005 Feb;139(2):247-52
pubmed: 15733984
Invest Ophthalmol Vis Sci. 2014 Nov 25;56(1):156-63
pubmed: 25425302
Am J Ophthalmol. 2002 May;133(5):679-85
pubmed: 11992866
Arch Ophthalmol. 1990 Jan;108(1):51-7
pubmed: 2297333
Ophthalmology. 2012 Jan;119(1):21-6.e1-3
pubmed: 21978594
Invest Ophthalmol Vis Sci. 2014 Mar 10;55(3):1419-26
pubmed: 24508789
J Glaucoma. 2012 Aug;21(6):394-400
pubmed: 21946540
Ophthalmology. 2018 Oct;125(10):1537-1546
pubmed: 29934269
Invest Ophthalmol Vis Sci. 2009 May;50(5):2165-74
pubmed: 19136694
Ophthalmology. 2017 Aug;124(8):1209-1217
pubmed: 28433445
Invest Ophthalmol Vis Sci. 2014 Feb 20;55(2):1048-55
pubmed: 24458157
J Glaucoma. 2018 Feb;27(2):189-196
pubmed: 29271810
Am J Ophthalmol. 2018 Aug;192:65-76
pubmed: 29750947
J Glaucoma. 2010 Mar;19(3):158-66
pubmed: 19661824
J Glaucoma. 2016 Nov;25(11):901-907
pubmed: 27755347
Invest Ophthalmol Vis Sci. 2013 Aug 13;54(8):5481-8
pubmed: 23847316
Am J Ophthalmol. 2008 Oct;146(4):496-500
pubmed: 18639219
J Glaucoma. 2015 Jun-Jul;24(5):389-95
pubmed: 25719231
Optometry. 2005 Nov;76(11):661-8
pubmed: 16298320
Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2357-2370
pubmed: 29847642
Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4597-607
pubmed: 17898283
Invest Ophthalmol Vis Sci. 1983 Jan;24(1):85-98
pubmed: 6826318
Am J Ophthalmol. 2013 Aug;156(2):218-227.e2
pubmed: 23768651
Invest Ophthalmol Vis Sci. 2011 Mar 02;52(3):1206-19
pubmed: 21217108
Br J Ophthalmol. 1998 Jun;82(6):680-3
pubmed: 9797672
Biomech Model Mechanobiol. 2009 Apr;8(2):85-98
pubmed: 18309526
Am J Ophthalmol. 2019 Mar;199:28-43
pubmed: 30414397
Sci Rep. 2017 Jul 19;7(1):5881
pubmed: 28725046
PLoS One. 2015 Apr 07;10(4):e0122191
pubmed: 25848777
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1464-74
pubmed: 19875649
J Glaucoma. 2012 Apr-May;21(4):260-5
pubmed: 21623226
Ophthalmology. 2012 Sep;119(9):1844-51
pubmed: 22595297
Ophthalmology. 2015 Sep;122(9):1786-94
pubmed: 26198806
Br J Ophthalmol. 2014 Apr;98(4):538-43
pubmed: 24390166
Arch Ophthalmol. 1991 Oct;109(10):1441-3
pubmed: 1929937
Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7661-78
pubmed: 26641545
Ophthalmology. 2011 Oct;118(10):2050-7
pubmed: 21820741
Exp Eye Res. 2015 Dec;141:125-38
pubmed: 26115620
Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4403-11
pubmed: 27564522
Invest Ophthalmol Vis Sci. 2014 Jun 03;55(7):4378-93
pubmed: 24894400
Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3195-208
pubmed: 17591889
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4709-18
pubmed: 19443718
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3515-23
pubmed: 20164448
Ophthalmology. 2012 Apr;119(4):738-47
pubmed: 22222150
Ophthalmology. 2018 Aug;125(8):1224-1233
pubmed: 29544962
Prog Retin Eye Res. 2005 Jan;24(1):39-73
pubmed: 15555526
Biomech Model Mechanobiol. 2009 Apr;8(2):99-109
pubmed: 18301933
Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1901-11
pubmed: 27088762
Invest Ophthalmol Vis Sci. 2012 Apr 18;53(4):1852-60
pubmed: 22410561
Am J Ophthalmol. 2014 Mar;157(3):540-9.e1-2
pubmed: 24239775
Nature. 1979 Dec 13;282(5740):720-2
pubmed: 514350
Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):2004-9
pubmed: 24595390
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):214-23
pubmed: 18689697
Int J Ophthalmol. 2013 Oct 18;6(5):626-31
pubmed: 24195037
Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4106-4113
pubmed: 28828482
J Neuroophthalmol. 2015 Sep;35 Suppl 1:S8-S21
pubmed: 26274837
Exp Eye Res. 2012 Dec;105:70-8
pubmed: 23099334
Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):197-205
pubmed: 27796669
Br J Ophthalmol. 2015 Jan;99(1):69-74
pubmed: 25091955
Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4927-35
pubmed: 26225633