Stimulus-responsive polymeric nanogels as smart drug delivery systems.

Animals Drug Delivery Systems Drug Liberation Humans Nanogels / chemistry Oxidation-Reduction Stimuli Responsive Polymers / chemical synthesis Temperature
Cancer treatment Drug delivery Nanogels Smart drug release Stimulus-responsive

Journal

Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144

Informations de publication

Date de publication:
01 07 2019
Historique:
received: 15 01 2019
revised: 01 05 2019
accepted: 06 05 2019
pubmed: 17 5 2019
medline: 2 7 2020
entrez: 17 5 2019
Statut: ppublish

Résumé

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This "smart" targeting ability prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. This review aims to provide an introduction to nanogels, their preparation methods, and to discuss the design of various stimulus-responsive nanogels that are able to provide controlled drug release in response to particular stimuli. STATEMENT OF SIGNIFICANCE: Smart and stimulus-responsive drug delivery is a rapidly growing area of biomaterial research. The explosive rise in nanotechnology and nanomedicine, has provided a host of nanoparticles and nanovehicles which may bewilder the uninitiated reader. This review will lay out the evidence that polymeric nanogels have an important role to play in the design of innovative drug delivery vehicles that respond to internal and external stimuli such as temperature, pH, redox, and light.

Identifiants

DOI: 10.1016/j.actbio.2019.05.018 PMID: 31096042 PMC: PMC6661071
pubmed: 31096042
pii: S1742-7061(19)30335-6
doi: 10.1016/j.actbio.2019.05.018
pmc: PMC6661071
mid: NIHMS1031625
pii:
doi:

Substances chimiques

Nanogels 0
Stimuli Responsive Polymers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-18

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI050875
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI121700
Pays : United States

Informations de copyright

Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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Auteurs

Sakineh Hajebi (S)

Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.

Navid Rabiee (N)

Department of Chemistry, Sharif University of Technology, Tehran, Iran.

Mojtaba Bagherzadeh (M)

Department of Chemistry, Sharif University of Technology, Tehran, Iran.

Sepideh Ahmadi (S)

Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Division of Diseases, Advanced Technologies Research Group, Tehran, Iran.

Mohammad Rabiee (M)

Biomaterials Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.

Hossein Roghani-Mamaqani (H)

Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.

Mohammadreza Tahriri (M)

Marquette University School of Dentistry, Milwaukee, WI 53233, USA. Electronic address: Mohammadreza.tahriri@marquette.edu.

Lobat Tayebi (L)

Marquette University School of Dentistry, Milwaukee, WI 53233, USA.

Michael R Hamblin (MR)

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, USA; Department of Dermatology, Harvard Medical School, Boston, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, USA. Electronic address: hamblin@helix.mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanogels › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux intelligents › Polymères réagissant aux stimuli › Stimulus-responsive polymeric nanogels as...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Stimulus-responsive polymeric nanogels as...