Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose.
Alcohol
Electrochemical sensor
Glucose
Tears
Vitamins
Wearable sensor
Journal
Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
received:
14
03
2019
revised:
26
04
2019
accepted:
30
04
2019
pubmed:
17
5
2019
medline:
20
11
2019
entrez:
17
5
2019
Statut:
ppublish
Résumé
We report on a wearable tear bioelectronic platform, integrating a microfluidic electrochemical detector into an eyeglasses nose-bridge pad, for non-invasive monitoring of key tear biomarkers. The alcohol-oxidase (AOx) biosensing fluidic system allowed real-time tear collection and direct alcohol measurements in stimulated tears, leading to the first wearable platform for tear alcohol monitoring. Placed outside the eye region this fully wearable tear-sensing platform addresses drawbacks of sensor systems involving direct contact with the eye as the contact lenses platform. Integrating the wireless electronic circuitry into the eyeglasses frame thus yielded a fully portable, convenient-to-use fashionable sensing device. The tear alcohol sensing concept was demonstrated for monitoring of alcohol intake in human subjects over multiple drinking courses, displaying good correlation to parallel BAC measurements. We also demonstrate for the first time the ability to monitor tear glucose outside the eye and the utility of wearable devices for monitoring vitamin nutrients in connection to enzymatic flow detector and rapid voltammetric scanning, respectively. These developments pave the way to build an effective eyeglasses system capable of chemical tear analysis.
Identifiants
pubmed: 31096082
pii: S0956-5663(19)30349-5
doi: 10.1016/j.bios.2019.04.058
pmc: PMC8372769
mid: NIHMS1707780
pii:
doi:
Substances chimiques
Alcohols
0
Vitamins
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-170Subventions
Organisme : NIAAA NIH HHS
ID : T32 AA013525
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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