Malaria impact on cognitive function of children in a peri-urban community in the Brazilian Amazon.
Anemia
/ complications
Brazil
/ epidemiology
Child
Child, Preschool
Cognition
Cohort Studies
Female
Humans
Infant
Malaria, Vivax
/ complications
Male
Malnutrition
/ complications
Morbidity
Plasmodium vivax
/ isolation & purification
Prevalence
Risk Factors
Surveys and Questionnaires
Urban Population
Children
Cognition
Malaria
Plasmodium vivax
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
16 May 2019
16 May 2019
Historique:
received:
13
07
2018
accepted:
06
05
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
9
8
2019
Statut:
epublish
Résumé
In Latin America, where Plasmodium vivax malaria is more prevalent, it is known that this species plays an important role in the sustainability of transmission, and can have an impact on morbidity in terms of anaemia, nutritional status, and cognitive development in children. The present study aimed to assess the impact of malaria infection on cognition of children in a peri-urban community in the Brazilian Amazon with moderate endemicity by applying Home Inventory and WPPSI-IV. A non-concurrent cohort study was designed and the cognitive, haematological, and nutritional profiles of the children were assessed. Children with documented malaria history were identified from official reported data. A total of 219 children aged between 2 and 7 years were enrolled. Although 205 (95%) children had normal birth weight, 177 (81%) were malnourished, and 35 (16%) had anaemia. Among the 100 (46%) children who experienced at least one episode of malaria, 89 (89%) children demonstrated low level of cognitive development. The findings showed that Plasmodium vivax malaria was an independent risk factor for low cognitive development. In addition to the known economic impact of malaria in the Amazon region, the study highlights the deleterious effects P. vivax malaria has on the socio-cultural development of the population.
Sections du résumé
BACKGROUND
BACKGROUND
In Latin America, where Plasmodium vivax malaria is more prevalent, it is known that this species plays an important role in the sustainability of transmission, and can have an impact on morbidity in terms of anaemia, nutritional status, and cognitive development in children.
METHODS
METHODS
The present study aimed to assess the impact of malaria infection on cognition of children in a peri-urban community in the Brazilian Amazon with moderate endemicity by applying Home Inventory and WPPSI-IV. A non-concurrent cohort study was designed and the cognitive, haematological, and nutritional profiles of the children were assessed. Children with documented malaria history were identified from official reported data.
RESULTS
RESULTS
A total of 219 children aged between 2 and 7 years were enrolled. Although 205 (95%) children had normal birth weight, 177 (81%) were malnourished, and 35 (16%) had anaemia. Among the 100 (46%) children who experienced at least one episode of malaria, 89 (89%) children demonstrated low level of cognitive development. The findings showed that Plasmodium vivax malaria was an independent risk factor for low cognitive development.
CONCLUSIONS
CONCLUSIONS
In addition to the known economic impact of malaria in the Amazon region, the study highlights the deleterious effects P. vivax malaria has on the socio-cultural development of the population.
Identifiants
pubmed: 31096985
doi: 10.1186/s12936-019-2802-2
pii: 10.1186/s12936-019-2802-2
pmc: PMC6524266
doi:
Types de publication
Journal Article
Langues
eng
Pagination
173Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 486989/2012-7
Références
Cad Saude Publica. 2001 Jan-Feb;17(1):99-105
pubmed: 11241932
Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2 Suppl):68-75
pubmed: 11425179
J Dev Behav Pediatr. 2002 Oct;23(5):353-64
pubmed: 12394524
Child Dev. 2003 Sep-Oct;74(5):1368-78
pubmed: 14552403
J Pediatr (Rio J). 2000 Nov-Dec;76(6):421-8
pubmed: 14647629
Am J Trop Med Hyg. 2003 Dec;69(6):582-8
pubmed: 14740872
J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):476-81
pubmed: 15774431
Psychol Rep. 2005 Apr;96(2):307-21
pubmed: 15941104
Child Dev. 2005 Jul-Aug;76(4):795-810
pubmed: 16026497
Parasitology. 1992 Jun;104 ( Pt 3):539-47
pubmed: 1641252
Pediatrics. 2006 Feb;117(2):e298-319
pubmed: 16452337
Pediatrics. 2007 Feb;119(2):e360-6
pubmed: 17224457
J Nutr. 2007 Dec;137(12):2756-62
pubmed: 18029495
Ann Trop Med Parasitol. 1991 Oct;85(5):551-68
pubmed: 1809249
Cad Saude Publica. 2008 Feb;24(2):427-37
pubmed: 18278290
BMC Pediatr. 2008 May 05;8:19
pubmed: 18457590
Trop Med Int Health. 2008 Aug;13(8):994-1004
pubmed: 18627581
Rev Obstet Gynecol. 2009 Summer;2(3):186-92
pubmed: 19826576
Malar J. 2009 Oct 16;8:230
pubmed: 19835584
BMC Res Notes. 2010 Apr 16;3:104
pubmed: 20398391
Malar J. 2010 Apr 30;9:115
pubmed: 20433744
Malar J. 2010 Dec 20;9:366
pubmed: 21171998
PLoS Negl Trop Dis. 2011 Jun;5(6):e1032
pubmed: 21666785
BMC Res Notes. 2012 Oct 11;5:565
pubmed: 23057857
BMC Psychiatry. 2013 Oct 22;13:274
pubmed: 24148567
PLoS Pathog. 2014 Mar 06;10(3):e1003980
pubmed: 24603727
Clin Infect Dis. 2014 Aug 1;59(3):336-44
pubmed: 24771329
Malar J. 2015 Oct 09;14:401
pubmed: 26453016
Rev Panam Salud Publica. 2015 Oct;38(4):300-6
pubmed: 26758221
PLoS One. 2016 Mar 10;11(3):e0151019
pubmed: 26963624
Nutr J. 2016 Apr 12;15:38
pubmed: 27067274
Malar J. 2017 Sep 12;16(1):370
pubmed: 28899387
Parasit Vectors. 2018 Mar 20;11(1):194
pubmed: 29558985
PLoS Negl Trop Dis. 2018 Jul 27;12(7):e0006688
pubmed: 30052640
Cent Afr J Med. 1997 Aug;43(8):231-4
pubmed: 9431762
Am Psychol. 1998 Feb;53(2):185-204
pubmed: 9491747
Cad Saude Publica. 1998 Apr 30;14(1):157-64
pubmed: 9592221