Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Carcinoma in Situ
/ etiology
Carcinoma, Squamous Cell
/ etiology
Diagnosis, Differential
Disease Progression
Female
Humans
Lichen Sclerosus et Atrophicus
/ complications
Neurodermatitis
/ complications
Papillomavirus Infections
/ complications
Precancerous Conditions
/ etiology
Prognosis
Vulvar Neoplasms
/ etiology
Differentiated exophytic vulvar intraepithelial lesion
Differentiated vulvar intraepithelial neoplasia
Verrucous carcinoma
Vulvar acanthosis with altered differentiation
Vulvar dermatoses
Journal
Surgical pathology clinics
ISSN: 1875-9157
Titre abrégé: Surg Pathol Clin
Pays: United States
ID NLM: 101491209
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
4
12
2019
Statut:
ppublish
Résumé
The pathogenesis of vulvar squamous neoplasia has 2 pathways: human papillomavirus (HPV)-dependent and HPV-independent. The HPV-dependent pathway in the vulva follows the same progression as HPV-dependent lesions elsewhere in the gynecologic tract-HPV infection results in high-grade squamous intraepithelial lesion with subsequent progression to basaloid squamous cell carcinoma. The HPV-independent pathway is more complex, with a variety of precursor lesions and molecular alterations. Although the most recognized form of HPV-independent vulvar lesion is differentiated vulvar intraepithelial neoplasia, recent explorations have elucidated new precursors. This review provides an update on HPV-independent risk factors and precursor lesions for squamous cell carcinoma of the vulva.
Identifiants
pubmed: 31097103
pii: S1875-9181(19)30003-0
doi: 10.1016/j.path.2019.01.001
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-261Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.