secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 05 2019
16 05 2019
Historique:
received:
25
06
2018
accepted:
10
04
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion.
Identifiants
pubmed: 31097722
doi: 10.1038/s41598-019-42849-9
pii: 10.1038/s41598-019-42849-9
pmc: PMC6522505
doi:
Substances chimiques
Chloride Channels
0
Chlorides
0
Dh44 protein, Drosophila
0
Drosophila Proteins
0
Insect Hormones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7464Subventions
Organisme : NIH HHS
ID : P40 OD018537
Pays : United States
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