Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
09 May 2019
09 May 2019
Historique:
received:
07
02
2019
accepted:
05
04
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
18
5
2019
Statut:
epublish
Résumé
Noncatechol heterocycles have recently been discovered as potent and selective G protein biased dopamine 1 receptor (D1R) agonists with superior pharmacokinetic properties. To determine the structure-activity relationships centered on G protein or β-arrestin signaling bias, systematic medicinal chemistry was employed around three aromatic pharmacophores of the lead compound
Identifiants
pubmed: 31098001
doi: 10.1021/acsmedchemlett.9b00050
pmc: PMC6511950
doi:
Types de publication
Journal Article
Retracted Publication
Langues
eng
Pagination
792-799Commentaires et corrections
Type : RetractionIn
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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