Wnt5a is a TLR2/4-ligand that induces tolerance in human myeloid cells.
Animals
Cells, Cultured
Cytokines
/ biosynthesis
Drosophila Proteins
/ chemistry
Humans
Immune Tolerance
Immunity, Innate
Interleukin-10
/ biosynthesis
Intracellular Signaling Peptides and Proteins
/ chemistry
Ligands
Mice
Models, Immunological
Models, Molecular
Myeloid Cells
/ immunology
NF-kappa B
/ metabolism
Signal Transduction
/ immunology
Toll-Like Receptor 2
/ immunology
Toll-Like Receptor 4
/ immunology
Toll-Like Receptors
/ chemistry
Transcription, Genetic
Wnt-5a Protein
/ immunology
Immune evasion
Monocytes and macrophages
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
11
2018
accepted:
18
04
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
18
5
2019
Statut:
epublish
Résumé
Innate immune responses are rapid, dynamic and highly regulated to avoid overt reactions. This regulation is executed by innate immune tolerance mechanisms that remain obscure. Wnt5a is a signalling protein mainly involved in developmental processes and cancer. The effect of Wnt5a on inflammatory myeloid cells is controversial. Here, we combine primary cell cultures, in vitro binding studies, mass spectrometry and
Identifiants
pubmed: 31098409
doi: 10.1038/s42003-019-0432-4
pii: 432
pmc: PMC6509336
doi:
Substances chimiques
Cytokines
0
Drosophila Proteins
0
IL10 protein, human
0
Intracellular Signaling Peptides and Proteins
0
Ligands
0
NF-kappa B
0
TLR2 protein, human
0
TLR4 protein, human
0
Tl protein, Drosophila
0
Toll-Like Receptor 2
0
Toll-Like Receptor 4
0
Toll-Like Receptors
0
WNT5A protein, human
0
Wnt-5a Protein
0
WntD protein, Drosophila
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
176Déclaration de conflit d'intérêts
The authors declare no competing interests.
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