Diagnostics of DNA fragmentation in human spermatozoa: Are sperm chromatin structure analysis and sperm chromatin dispersion tests (SCD-HaloSpermG2
SCD
SCSA
idiopathic infertility
semen analyses
sperm DNA fragmentation
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
14
03
2019
revised:
15
04
2019
accepted:
26
04
2019
pubmed:
18
5
2019
medline:
15
2
2020
entrez:
18
5
2019
Statut:
ppublish
Résumé
Men affected with idiopathic infertility often display basic spermiogramme values similar to fertile individuals, questioning the diagnostic impact of the World Health Organization (WHO) thresholds used. This study explored sperm DNA fragmentation in single ejaculates from 14 fertile donors and 42 patients with idiopathic infertility providing semen for assisted reproductive techniques in a university fertility clinic. Each ejaculate was simultaneously studied for sperm DNA fragmentation by the flow cytometer-based sperm chromatin structure analysis (SCSA) and the new light-microscopy-based sperm chromatin dispersion assay (SCD-HaloSpermG2
Substances chimiques
Chromatin
0
Types de publication
Comparative Study
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13316Subventions
Organisme : Forskningsrådet i Sydöstra Sverige
ID : 473121
Organisme : Forskningsrådet i Sydöstra Sverige
ID : 745971
Organisme : Lions Forskningsfond
ID : DNR LIU-2016-00641
Organisme : Svenska Forskningsrådet Formas
ID : 2017-00946
Organisme : ALF-Research (Region Östergötland)
ID : LIO-698951
Informations de copyright
© 2019 Blackwell Verlag GmbH.