Precision, reproducibility and applicability of an undersampled multi-venc 4D flow MRI sequence for the assessment of cardiac hemodynamics.
4D flow MRI
Blood flow quantification
Multi-venc
k-t PCA
Journal
Magnetic resonance imaging
ISSN: 1873-5894
Titre abrégé: Magn Reson Imaging
Pays: Netherlands
ID NLM: 8214883
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
01
09
2018
revised:
05
03
2019
accepted:
06
05
2019
pubmed:
18
5
2019
medline:
4
1
2020
entrez:
18
5
2019
Statut:
ppublish
Résumé
For the assessment of cardiovascular blood flow, 2D flow (2D) and 4D flow with a single venc (4D Mono) are established techniques. The objective of this study was to validate a multi-venc 4D flow (4D Multi) sequence for the improved simultaneous assessment of arterial and venous flow in high and low flow conditions and to investigate the scan-rescan reproducibility and inter-observer variability of the novel sequence. Eleven volunteers with no known heart condition (female: 6, mean age: 25.8 ± 9.1 years) and two patients with a Fontan circulation were examined using phase-contrast 2D and 4D flow MRI. Stroke volumes, maximum velocities, net flow curves and internal consistency were measured and compared between 2D, 4D Mono and 4D Multi. Additionally, scan-rescan and inter-observer variabilities were analyzed. Finally, qualitative visualization comparisons were performed. Bland-Altman analysis show a higher agreement in stroke volumes between 4D Multi and 2D (7 ± 11%) than 4D Mono and 2D (11 ± 24%). 4D Multi is more accurate than 4D Mono in measuring time-resolved net flow throughout the cardiac cycle and qualitative blood flow visualization of 4D Multi is more accurate in visualizing flow patterns revealing more details and less artifacts than 4D Mono. Scan-rescan reproducibility is higher in 4D Multi (-0.04 ± 4.5 ml) than 2D (2.1 ± 7.3 ml) and inter-observer variability is low in both techniques (2D: -0.4 ± 3.4 ml and 4D Multi: 0.4 ± 3.5 ml). Internal consistency was improved in volunteers and patients when using 4D Multi as compared to 4D Mono. 4D Multi offers a comprehensive way to accurately quantify flow in arteries and veins both in high and low flow situations and to visualize detailed flow patterns. This technique is readily applicable in the clinical setting and has the potential to be beneficial in the clinical assessment of valvular and congenital heart diseases.
Sections du résumé
BACKGROUND AND PURPOSE
For the assessment of cardiovascular blood flow, 2D flow (2D) and 4D flow with a single venc (4D Mono) are established techniques. The objective of this study was to validate a multi-venc 4D flow (4D Multi) sequence for the improved simultaneous assessment of arterial and venous flow in high and low flow conditions and to investigate the scan-rescan reproducibility and inter-observer variability of the novel sequence.
METHODS
Eleven volunteers with no known heart condition (female: 6, mean age: 25.8 ± 9.1 years) and two patients with a Fontan circulation were examined using phase-contrast 2D and 4D flow MRI. Stroke volumes, maximum velocities, net flow curves and internal consistency were measured and compared between 2D, 4D Mono and 4D Multi. Additionally, scan-rescan and inter-observer variabilities were analyzed. Finally, qualitative visualization comparisons were performed.
RESULTS
Bland-Altman analysis show a higher agreement in stroke volumes between 4D Multi and 2D (7 ± 11%) than 4D Mono and 2D (11 ± 24%). 4D Multi is more accurate than 4D Mono in measuring time-resolved net flow throughout the cardiac cycle and qualitative blood flow visualization of 4D Multi is more accurate in visualizing flow patterns revealing more details and less artifacts than 4D Mono. Scan-rescan reproducibility is higher in 4D Multi (-0.04 ± 4.5 ml) than 2D (2.1 ± 7.3 ml) and inter-observer variability is low in both techniques (2D: -0.4 ± 3.4 ml and 4D Multi: 0.4 ± 3.5 ml). Internal consistency was improved in volunteers and patients when using 4D Multi as compared to 4D Mono.
CONCLUSION
4D Multi offers a comprehensive way to accurately quantify flow in arteries and veins both in high and low flow situations and to visualize detailed flow patterns. This technique is readily applicable in the clinical setting and has the potential to be beneficial in the clinical assessment of valvular and congenital heart diseases.
Identifiants
pubmed: 31100318
pii: S0730-725X(18)30431-4
doi: 10.1016/j.mri.2019.05.015
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-82Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.