Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis - a pilot study.
Adult
Aged
Amyotrophic Lateral Sclerosis
/ blood
Antigens, CD34
/ metabolism
Blood Cell Count
Colony-Forming Units Assay
Cytokines
/ blood
Dose-Response Relationship, Drug
Female
Granulocyte Colony-Stimulating Factor
/ administration & dosage
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cells
/ drug effects
Humans
Male
Middle Aged
Pilot Projects
Telomere Homeostasis
Amyotrophic lateral sclerosis, ALS
Cytokines
Granulocyte-colony stimulating factor, G-CSF
Hematopoietic stem and progenitor cells, HSPC
Telomere length
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
09
2018
revised:
23
04
2019
accepted:
05
05
2019
pubmed:
18
5
2019
medline:
19
8
2020
entrez:
18
5
2019
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of complex and still poorly understood etiology. Loss of upper and lower motoneurons results in death within few years after diagnosis. Recent studies have proposed neuroprotective and disease-slowing effects of granulocyte-colony stimulating factor (G-CSF) treatment in ALS mouse models as well as humans. In this study, six ALS patients were monitored up to 3.5 years during continuous high-dose G-CSF administration. Repetitive analyses were performed including blood count parameters, CD34
Identifiants
pubmed: 31100684
pii: S1043-4666(19)30120-6
doi: 10.1016/j.cyto.2019.05.003
pii:
doi:
Substances chimiques
Antigens, CD34
0
Cytokines
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-201Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.