Antiviral RNAi in Insects and Mammals: Parallels and Differences.
RNA interference
RNA virus
antiviral defense
innate immunity
interferon
small interfering RNA
stem cells
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
16 05 2019
16 05 2019
Historique:
received:
16
04
2019
revised:
14
05
2019
accepted:
15
05
2019
entrez:
19
5
2019
pubmed:
19
5
2019
medline:
28
7
2020
Statut:
epublish
Résumé
The RNA interference (RNAi) pathway is a potent antiviral defense mechanism in plants and invertebrates, in response to which viruses evolved suppressors of RNAi. In mammals, the first line of defense is mediated by the type I interferon system (IFN); however, the degree to which RNAi contributes to antiviral defense is still not completely understood. Recent work suggests that antiviral RNAi is active in undifferentiated stem cells and that antiviral RNAi can be uncovered in differentiated cells in which the IFN system is inactive or in infections with viruses lacking putative viral suppressors of RNAi. In this review, we describe the mechanism of RNAi and its antiviral functions in insects and mammals. We draw parallels and highlight differences between (antiviral) RNAi in these classes of animals and discuss open questions for future research.
Identifiants
pubmed: 31100912
pii: v11050448
doi: 10.3390/v11050448
pmc: PMC6563508
pii:
doi:
Substances chimiques
Antiviral Agents
0
Interferon Type I
0
MicroRNAs
0
RNA, Small Interfering
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : ERC CoG 615680
Pays : International
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