Expression of Glypican 3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes.

antibody secreting cell biomarker breast cancer immune profile immunotherapy lymph node microarray tumor antigen

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
16 May 2019
Historique:
received: 14 04 2019
revised: 02 05 2019
accepted: 13 05 2019
entrez: 19 5 2019
pubmed: 19 5 2019
medline: 19 5 2019
Statut: epublish

Résumé

Exosomes are nano-sized membranous vesicles of endosomal origin that carry nucleic acids, lipids and proteins. The cargo of exosomes is cell origin specific and the release of these exosomes and uptake by an acceptor cell is seen as a vital element of cell-cell communication. Here, we sought to investigate the diagnostic and prognostic value of the expression of glypican 3 (

Identifiants

pubmed: 31100935
pii: jcm8050696
doi: 10.3390/jcm8050696
pmc: PMC6572603
pii:
doi:

Types de publication

Journal Article

Langues

eng

Déclaration de conflit d'intérêts

The authors declare no conflict of interest. The funders had no role in the design of the study; the collection, analyses, or interpretation of data; the writing of the manuscript, or in the decision to publish these results.

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Auteurs

Mohammad Rahbari (M)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Mohammad.Rahbari@uniklinikum-dresden.de.

Mathieu Pecqueux (M)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Mathieu.Pecqueux@uniklinikum-dresden.de.

Daniela Aust (D)

Institute for Pathology, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Daniela.Aust@uniklinikum-dresden.de.
Tumor and Normal Tissue Bank of the University Cancer Center, Technical University Dresden, D-01307 Dresden, Germany. Daniela.Aust@uniklinikum-dresden.de.

Holger Stephan (H)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, D-01328 Dresden, Germany. h.stephan@hzdr.de.

Oliver Tiebel (O)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. oliver.tiebel@uniklinikum-dresden.de.

Antonios Chatzigeorgiou (A)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. antonios.chatzigeorgiou@uniklinikum-dresden.de.

Torsten Tonn (T)

Institute for Transfusion Medicine, German Red Cross Blood Donation Service North-East, D-01307 Dresden, Germany. t.tonn@blutspende.de.
Medical Faculty, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. t.tonn@blutspende.de.

Franziska Baenke (F)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Franziska.Baenke@uniklinikum-dresden.de.
German Cancer Consortium (DKTK) German Cancer Research Centre (DKFZ), D-69120 Heidelberg, Germany. Franziska.Baenke@uniklinikum-dresden.de.

Venkatesh Rao (V)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Rao.Venkatesh@uniklinikum-dresden.de.

Nicole Ziegler (N)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Nicole.Ziegler@uniklinikum-dresden.de.
German Cancer Consortium (DKTK) German Cancer Research Centre (DKFZ), D-69120 Heidelberg, Germany. Nicole.Ziegler@uniklinikum-dresden.de.

Helena Greif (H)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Helena.Greif@uniklinikum-dresden.de.

Kuailu Lin (K)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Kuailu.Lin@uniklinikum-dresden.de.

Juergen Weitz (J)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Juergen.Weitz@uniklinikum-dresden.de.

Nuh Nabi Rahbari (NN)

Department of Surgery, University Medicine Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, D-68167 Mannheim, Germany. Nuh.Rahbari@umm.de.

Christoph Kahlert (C)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, D-01307 Dresden, Germany. Christoph.Kahlert@uniklinikum-dresden.de.
German Cancer Consortium (DKTK) German Cancer Research Centre (DKFZ), D-69120 Heidelberg, Germany. Christoph.Kahlert@uniklinikum-dresden.de.

Classifications MeSH