Role of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress.

Animals Behavior, Animal Bone Marrow Transplantation Depression / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs / genetics Monocytes / metabolism Resilience, Psychological Stress, Psychological / metabolism Transplantation Chimera
Immune system Leukocyte Major depressive disorder Resilience Stress microRNA

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
15 09 2019
Historique:
received: 13 08 2018
revised: 13 02 2019
accepted: 28 02 2019
pubmed: 19 5 2019
medline: 15 8 2020
entrez: 19 5 2019
Statut: ppublish

Résumé

Clinical studies suggest that heightened peripheral inflammation contributes to the pathogenesis of stress-related disorders, including major depressive disorder. However, the molecular mechanisms within peripheral immune cells that mediate enhanced stress vulnerability are not well known. Because microRNAs (miRs) are important regulators of immune response, we sought to examine their role in mediating inflammatory and behavioral responses to repeated social defeat stress (RSDS), a mouse model of stress vulnerability that produces susceptible and resilient phenotypes. We isolated Ly6c We found that RSDS produces an increase in circulating Ly6c Our results identify the miR-106b∼25 cluster as a key regulator of stress-induced inflammation and depression that may represent a novel therapeutic target for drug development.

Sections du résumé

BACKGROUND
Clinical studies suggest that heightened peripheral inflammation contributes to the pathogenesis of stress-related disorders, including major depressive disorder. However, the molecular mechanisms within peripheral immune cells that mediate enhanced stress vulnerability are not well known. Because microRNAs (miRs) are important regulators of immune response, we sought to examine their role in mediating inflammatory and behavioral responses to repeated social defeat stress (RSDS), a mouse model of stress vulnerability that produces susceptible and resilient phenotypes.
METHODS
We isolated Ly6c
RESULTS
We found that RSDS produces an increase in circulating Ly6c
CONCLUSIONS
Our results identify the miR-106b∼25 cluster as a key regulator of stress-induced inflammation and depression that may represent a novel therapeutic target for drug development.

Identifiants

DOI: 10.1016/j.biopsych.2019.02.023 PMID: 31101319 PMC: PMC6717005
pubmed: 31101319
pii: S0006-3223(19)31147-3
doi: 10.1016/j.biopsych.2019.02.023
pmc: PMC6717005
mid: NIHMS1529712
pii:
doi:

Substances chimiques

MicroRNAs 0
Mirn106 microRNA, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

474-482

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH104559
Pays : United States
Organisme : NIMH NIH HHS
ID : F31 MH105217
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH087004
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078207
Pays : United States
Organisme : NCCIH NIH HHS
ID : P50 AT008661
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH096678
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH096890
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH114882
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH090264
Pays : United States

Informations de copyright

Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Références

Diabetes Care. 2001 Jun;24(6):1069-78
pubmed: 11375373
Am Fam Physician. 2001 Aug 15;64(4):641-8
pubmed: 11529263
Biol Psychiatry. 2003 Aug 1;54(3):227-40
pubmed: 12893099
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):201-17
pubmed: 15694227
J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):469-75
pubmed: 15774430
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
J Psychiatr Res. 1992 Apr;26(2):125-34
pubmed: 1613679
Science. 2006 Feb 10;311(5762):864-8
pubmed: 16469931
Annu Rev Immunol. 2006;24:99-146
pubmed: 16551245
J Neurobiol. 2006 May;66(6):552-63
pubmed: 16555237
Diabet Med. 2006 Nov;23(11):1165-73
pubmed: 17054590
BMC Genomics. 2007 Jun 12;8:166
pubmed: 17565689
Arthritis Rheum. 2007 Sep;56(9):2975-85
pubmed: 17763443
Cell. 2007 Oct 19;131(2):391-404
pubmed: 17956738
Mol Psychiatry. 2009 May;14(5):532-6
pubmed: 18779818
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5761-6
pubmed: 19307576
Cell. 2009 Nov 13;139(4):693-706
pubmed: 19878981
Biol Psychiatry. 2010 Mar 1;67(5):446-57
pubmed: 20015486
BMC Genomics. 2010 May 07;11:288
pubmed: 20459673
Mol Cell. 2010 Jul 9;39(1):133-44
pubmed: 20603081
Circ Res. 2010 Sep 17;107(6):810-7
pubmed: 20651284
EMBO J. 2011 May 18;30(10):1977-89
pubmed: 21468030
FEBS Lett. 2011 Jun 23;585(12):1963-8
pubmed: 21609717
J Allergy Clin Immunol. 2011 Nov;128(5):1077-85.e1-10
pubmed: 21616524
J Neurosci. 2011 Jun 22;31(25):9084-92
pubmed: 21697359
Nat Protoc. 2011 Jul 21;6(8):1183-91
pubmed: 21799487
Oncogene. 2012 Dec 13;31(50):5162-71
pubmed: 22286770
Immunol Lett. 2012 Aug 30;146(1-2):25-30
pubmed: 22546503
Pharmacogenomics. 2012 Jul;13(10):1129-39
pubmed: 22909203
Eur Neuropsychopharmacol. 2013 Jul;23(7):602-11
pubmed: 22925464
Nat Med. 2012 Oct;18(10):1518-24
pubmed: 23023500
Transl Psychiatry. 2012 Nov 13;2:e185
pubmed: 23149449
PLoS One. 2013 Jul 29;8(7):e69807
pubmed: 23922807
J Neurosci. 2013 Aug 21;33(34):13820-33
pubmed: 23966702
PLoS One. 2013 Aug 19;8(8):e71637
pubmed: 23977098
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16574-9
pubmed: 24062448
Front Genet. 2014 Apr 23;5:99
pubmed: 24795757
Nat Rev Immunol. 2014 Jun;14(6):392-404
pubmed: 24854589
World J Gastroenterol. 2014 May 28;20(20):5962-72
pubmed: 24876719
Nat Med. 2014 Jul;20(7):754-758
pubmed: 24952646
Neuron. 2014 Jul 16;83(2):344-360
pubmed: 24952960
Front Genet. 2014 Jun 12;5:178
pubmed: 24971086
Curr Top Microbiol Immunol. 2014;380:145-55
pubmed: 25004817
J Psychiatr Res. 2014 Dec;59:45-52
pubmed: 25201637
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16136-41
pubmed: 25331895
Circ Cardiovasc Genet. 2015 Feb;8(1):11-20
pubmed: 25466411
Mult Scler. 2015 Mar;21(3):305-17
pubmed: 25583845
J Neurosci. 2015 Jan 28;35(4):1530-8
pubmed: 25632130
PLoS One. 2015 Mar 12;10(3):e0121975
pubmed: 25763923
Nat Commun. 2015 Mar 16;6:6431
pubmed: 25775432
Nat Neurosci. 2015 Oct;18(10):1386-93
pubmed: 26404713
Sci Rep. 2016 Jan 19;6:19406
pubmed: 26783261
J Psychiatr Res. 2016 Jul;78:65-71
pubmed: 27078210
J Affect Disord. 2016 Aug;200:250-8
pubmed: 27152760
Neuropsychopharmacology. 2017 Jan;42(1):62-80
pubmed: 27291462
Nat Neurosci. 2017 Dec;20(12):1752-1760
pubmed: 29184215
Nat Commun. 2018 Feb 2;9(1):477
pubmed: 29396460
Cytokine. 1997 Nov;9(11):853-8
pubmed: 9367546

Auteurs

Madeline L Pfau (ML)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Caroline Menard (C)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry and Neuroscience, Faculty of Medicine and Cervo Brain Research Center, Université Laval, Quebec City, Quebec, Canada.

Flurin Cathomas (F)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Fiona Desland (F)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Oncological Science, Tisch Cancer Institute and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Veronika Kana (V)

Department of Oncological Science, Tisch Cancer Institute and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Kenny L Chan (KL)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Yusuke Shimo (Y)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Katherine LeClair (K)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Meghan E Flanigan (ME)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Hossein Aleyasin (H)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Deena M Walker (DM)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Sylvain Bouchard (S)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.

Matthias Mack (M)

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Georgia E Hodes (GE)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.

Miriam M Merad (MM)

Department of Oncological Science, Tisch Cancer Institute and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Scott J Russo (SJ)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: scott.russo@mssm.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation de moelle osseuse › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Phénomènes psychologiques › Résilience psychologique › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Phénomènes psychologiques › Stress psychologique › Role of Monocyte-Derived MicroRNA106b∼25 in...
questionsmedicales.fr › Stades d'organismes › Chimère › Chimère obtenue par transplantation › Role of Monocyte-Derived MicroRNA106b∼25 in...