Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials.
Clinically Meaningful Change
Sexual Desire
Sexual Function Assessment
Testosterone Treatment
Journal
The journal of sexual medicine
ISSN: 1743-6109
Titre abrégé: J Sex Med
Pays: Netherlands
ID NLM: 101230693
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
11
02
2019
revised:
29
03
2019
accepted:
03
04
2019
pubmed:
19
5
2019
medline:
24
6
2020
entrez:
19
5
2019
Statut:
ppublish
Résumé
A recent study of older men participating in the Testosterone Trials (TTrials) defined a clinically meaningful change in the Psychosexual Daily Questionnaire (PDQ) question 4 in hypogonadal men age ≥65 years. This study defines clinically meaningful change in the same population for sexual desire assessed by PDQ question 1. To determine a clinically meaningful change in the answers to question 1 of the PDQ in hypogonadal older men. Participants in the Sexual Function Trial of the TTrials were randomly divided into a training and test set. Anchor-based methods, including regression analysis, receiver operating characteristic curves, and empirical cumulative distribution functions, were used to determine a clinically meaningful change on question 1 in the training set, and the selected threshold was evaluated in the test set for an effect of testosterone treatment. A clinically meaningful increase in question 1 of the PDQ was determined to be ≥0.7 points. Question 1 of the PDQ can be used to assess sexual desire in response to testosterone treatment. Data were obtained from a single large study of older hypogonadal men. Clinically meaningful improvement of sexual desire is a change of ≥0.7 in the score of question 1 of the PDQ. Stephens-Shields AJ, Wang C, Preston P, et al. Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials. J Sex Med 2019;16:951-953.
Sections du résumé
BACKGROUND
A recent study of older men participating in the Testosterone Trials (TTrials) defined a clinically meaningful change in the Psychosexual Daily Questionnaire (PDQ) question 4 in hypogonadal men age ≥65 years. This study defines clinically meaningful change in the same population for sexual desire assessed by PDQ question 1.
AIM
To determine a clinically meaningful change in the answers to question 1 of the PDQ in hypogonadal older men.
METHODS
Participants in the Sexual Function Trial of the TTrials were randomly divided into a training and test set. Anchor-based methods, including regression analysis, receiver operating characteristic curves, and empirical cumulative distribution functions, were used to determine a clinically meaningful change on question 1 in the training set, and the selected threshold was evaluated in the test set for an effect of testosterone treatment.
RESULTS
A clinically meaningful increase in question 1 of the PDQ was determined to be ≥0.7 points.
CLINICAL IMPLICATIONS
Question 1 of the PDQ can be used to assess sexual desire in response to testosterone treatment.
STRENGTHS & LIMITATIONS
Data were obtained from a single large study of older hypogonadal men.
CONCLUSION
Clinically meaningful improvement of sexual desire is a change of ≥0.7 in the score of question 1 of the PDQ. Stephens-Shields AJ, Wang C, Preston P, et al. Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials. J Sex Med 2019;16:951-953.
Identifiants
pubmed: 31101538
pii: S1743-6095(19)31110-5
doi: 10.1016/j.jsxm.2019.04.003
pmc: PMC7359814
mid: NIHMS1529739
pii:
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
951-953Subventions
Organisme : NIA NIH HHS
ID : U01 AG030644
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Informations de copyright
Copyright © 2019 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
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