Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding.
binding sites
coagulation factor V
coagulation factor Xa
prothrombin activation
prothrombinase complex
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
12
2018
revised:
02
05
2019
accepted:
07
05
2019
pubmed:
19
5
2019
medline:
15
7
2020
entrez:
19
5
2019
Statut:
ppublish
Résumé
Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. In the presence of an anionic phospholipid membrane and calcium ions, factors Va and Xa assemble into the prothrombinase complex. Following formation of the ternary complex with the macromolecular zymogen substrate prothrombin, the latter is rapidly converted into thrombin, the key regulatory enzyme of coagulation. Over the years, multiple binding sites have been identified in factor Va that play a role in the interaction of the cofactor with factor Xa, prothrombin, or the anionic phospholipid membrane surface. In this review, an overview of the currently available information on these interactive sites in factor Va is provided, and data from biochemical approaches and 3D structural protein complex models are discussed. The structural models have been generated in recent years and provide novel insights into the molecular requirements for assembly of both the prothrombinase and the ternary prothrombinase-prothrombin complexes. Integrated knowledge of functionally important regions in factor Va will allow for a better understanding of factor Va cofactor activity.
Identifiants
pubmed: 31102425
doi: 10.1111/jth.14487
pmc: PMC6851895
pii: S1538-7836(22)14309-6
doi:
Substances chimiques
Phospholipids
0
Factor Va
65522-14-7
Prothrombin
9001-26-7
Thromboplastin
9035-58-9
Factor Xa
EC 3.4.21.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1229-1239Informations de copyright
© 2019 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.
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