Rapid and continuous accumulation of nitric oxide-releasing liposomes in tumors to augment the enhanced permeability and retention (EPR) effect.
Blood flow modulation
EPR effect
Nitric oxide
PEGylated liposome
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Jun 2019
30 Jun 2019
Historique:
received:
26
02
2019
revised:
29
04
2019
accepted:
14
05
2019
pubmed:
19
5
2019
medline:
18
12
2019
entrez:
19
5
2019
Statut:
ppublish
Résumé
The modulation of blood flow to tumors is a prominent strategy for improving the tumor accumulation of nanomedicines, resulting from the enhanced permeability and retention (EPR) effect. We previously reported a promising EPR enhancer-a nitric oxide (NO) donor-containing liposome (NO-LP)-which showed enhanced accumulation in tumor tissue. Herein, we study NO-LP in greater detail to clarify its practical use as an EPR enhancer. NO-LP was found to have advantages as a NO donor, including the ability to maintain NO donation over long periods of time, and a constant rate of NO-release irrespective of the environmental pH. NO-LP showed rapid accumulation in tumor tissue after injection (1 h), and then accumulation was continuously enhanced until 48 h. Enhanced NO-LP accumulation was observed specifically in tumor, while the accumulation in other organs remained relatively unchanged. The results obtained show the promising features of NO-LP as an EPR enhancer.
Identifiants
pubmed: 31102802
pii: S0378-5173(19)30402-8
doi: 10.1016/j.ijpharm.2019.05.043
pii:
doi:
Substances chimiques
Liposomes
0
Nitric Oxide Donors
0
Nitroso Compounds
0
2,2'-(hydroxynitrosohydrazono)bis-ethanamine
146724-94-9
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-487Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.