Strategizing biodegradable polymeric nanoparticles to cross the biological barriers for cancer targeting.
Biological barriers
Malignant cancer
Multi-drug resistance
Polymeric nanoparticles
Solid tumors
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Jun 2019
30 Jun 2019
Historique:
received:
10
02
2019
revised:
13
05
2019
accepted:
14
05
2019
pubmed:
19
5
2019
medline:
18
12
2019
entrez:
19
5
2019
Statut:
ppublish
Résumé
The biological barriers in the body have been fabricated by nature to protect the body from foreign molecules. The successful delivery of drugs is limited and being challenged by these biological barriers including the gastrointestinal tract, brain, skin, lungs, nose, mouth mucosa, and immune system. In this review article, we envisage to understand the functionalities of these barriers and revealing various drug-loaded biodegradable polymeric nanoparticles to overcome these barriers and deliver the entrapped drugs to cancer targeted site. Apart from it, tissue-specific multifunctional ligands, linkers and transporters when employed imparts an effective active delivery strategy by receptor-mediated transcytosis. Together, these strategies enable to deliver various drugs across the biological membranes for the treatment of solid tumors and malignant cancer.
Identifiants
pubmed: 31102804
pii: S0378-5173(19)30401-6
doi: 10.1016/j.ijpharm.2019.05.042
pii:
doi:
Substances chimiques
Polymers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
509-522Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.