The Adult Adrenal Cortex Undergoes Rapid Tissue Renewal in a Sex-Specific Manner.
adrenal stem cells
cell lineage tracing
sex hormones
sexual dimorphism
tissue homeostasis
Journal
Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
31
12
2018
revised:
13
03
2019
accepted:
11
04
2019
pubmed:
21
5
2019
medline:
15
8
2020
entrez:
21
5
2019
Statut:
ppublish
Résumé
Evolution has resulted in profound differences between males and females that extend to non-reproductive organs and are reflected in the susceptibility and progression of diseases. However, the cellular and molecular basis for these differences remains largely unknown. Here we report that adrenal gland tissue renewal is highly active and sexually dimorphic, with female mice showing a 3-fold higher turnover than males. Moreover, in males, homeostasis relies on proliferation of cells within the steroidogenic zone, but females employ an additional stem and/or progenitor compartment situated in the adrenal capsule. Using lineage tracing, sex reversal models, gonadectomy, and dihydrotestosterone treatments, we further show that sex-specific stem cell activity is driven by male hormones that repress recruitment of Gli1
Identifiants
pubmed: 31104943
pii: S1934-5909(19)30161-4
doi: 10.1016/j.stem.2019.04.012
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
290-296.e2Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.