Declining Skeletal Muscle Mitochondrial Function Associated With Increased Risk of Depression in Later Life.
Mitochondrial function
aging
depression
fatigue
longitudinal
Journal
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
26
11
2018
revised:
29
03
2019
accepted:
29
03
2019
pubmed:
21
5
2019
medline:
29
8
2020
entrez:
21
5
2019
Statut:
ppublish
Résumé
Late-life depression (LLD) is a chronic and heterogeneous disorder. Recent studies have implicated non-normative age-related processes in its pathogenesis. This investigation examined both cross-sectional and longitudinal associations between skeletal muscle mitochondrial function and LLD. Data from 603 men and women from the Baltimore Longitudinal Study on Aging were analyzed, of whom 167 provided data from a follow-up visit. Muscle bioenergetics was measured by postexercise recovery rate of phosphocreatine (PCr) using phosphorus magnetic resonance spectroscopy. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) Scale. There was no cross-sectional association between baseline depression status and either the PCr recovery rate constant (kPCr; t = -0.553, df = 542; p = 0.580) or mitochondrial capacity largely independent of exercise intensity (adenosine triphosphate maximum [ATP Findings suggest that declining skeletal muscle mitochondrial function in older adults is associated with clinically significant depressive symptoms at follow-up, thereby providing preliminary support for the hypothesis that mitochondrial dysfunction may be a potential key pathophysiological mechanism in adults with LLD.
Identifiants
pubmed: 31104966
pii: S1064-7481(19)30333-1
doi: 10.1016/j.jagp.2019.03.022
pmc: PMC7388241
mid: NIHMS1048690
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
963-971Subventions
Organisme : NIMH NIH HHS
ID : K01 MH113850
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH099097
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 AG999999
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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