BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury.
BDNF
TrkB
cardiovascular system
myocardial infarction
myocyte
vascular injury
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
07
2018
accepted:
01
04
2019
entrez:
21
5
2019
pubmed:
21
5
2019
medline:
21
5
2019
Statut:
epublish
Résumé
The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal development and modulating synaptic activity have been extensively studied and well established. Equally important roles for this growth factor have been uncovered in the cardiovascular system, through the examination of gene targeted animals to define critical actions in development, and to the unexpected roles of BDNF in modulating the response of the heart and vasculature to injury. Here we review the compartmentally distinct realm of cardiac myocytes, vascular smooth muscle cells, endothelial cells, and hematopoietic cells, focusing upon the actions of BDNF to modulate contractility, migration, neoangiogenesis, apoptosis and survival. These studies indicate that BDNF is an important growth factor which directs the response of the cardiovascular system to acute and chronic injury.
Identifiants
pubmed: 31105581
doi: 10.3389/fphys.2019.00455
pmc: PMC6498408
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
455Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL046403
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS030687
Pays : United States
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