A novel conserved family of Macro-like domains-putative new players in ADP-ribosylation signaling.
Bioinformatics
DUF2362
Intellectual disability
Macrodomain ADP-ribosilation
Novel enzyme families
Protein structure prediction
Uncharacterized proteins
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
02
2019
accepted:
28
03
2019
entrez:
21
5
2019
pubmed:
21
5
2019
medline:
21
5
2019
Statut:
epublish
Résumé
The presence of many completely uncharacterized proteins, even in well-studied organisms such as humans, seriously hampers a full understanding of the functioning of living cells. One such example is the human protein C12ORF4, which belongs to the DUF2362 family, present in many eukaryotic lineages and conserved in metazoans. The only functional information available on C12ORF4 (Chromosome 12 Open Reading Frame 4) is its involvement in mast cell degranulation and its being a genetic cause of autosomal intellectual disability. Bioinformatics analysis of the DUF2362 family provides strong evidence that it is a novel member of the Macro clan/superfamily. Sequence similarity analysis versus other representatives of the Macro superfamily of ADP-ribose-binding proteins and mapping sequence conservation on predicted three-dimensional structure provides hypotheses regarding the molecular function for members of the DUF2362 family. For example, the available functional data suggest a possible role for C12ORF4 in ADP-ribosylation signaling in asthma and related inflammatory diseases. This novel family appears to be a likely novel ADP-ribosylation "reader" and "eraser," a previously unnoticed putative new player in cell signaling by this emerging post-translational modification.
Identifiants
pubmed: 31106069
doi: 10.7717/peerj.6863
pii: 6863
pmc: PMC6500376
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e6863Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Science. 1999 Nov 5;286(5442):1153-5
pubmed: 10550052
J Mol Biol. 2003 Jul 11;330(3):503-11
pubmed: 12842467
J Pharmacol Exp Ther. 2004 Dec;311(3):1241-8
pubmed: 15254147
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Bioinformatics. 2004 Dec 12;20(18):3702-4
pubmed: 15284097
EMBO J. 2005 Jun 1;24(11):1911-20
pubmed: 15902274
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8
pubmed: 15980461
Nucleic Acids Res. 2008 Jan;36(Database issue):D735-40
pubmed: 18056084
Brief Funct Genomic Proteomic. 2008 Jul;7(4):283-90
pubmed: 18641417
J Mol Biol. 2009 Jan 9;385(1):212-25
pubmed: 18983849
Genome Res. 2009 Feb;19(2):327-35
pubmed: 19029536
Bioinformatics. 2009 May 1;25(9):1189-91
pubmed: 19151095
J Biol Chem. 2011 Apr 15;286(15):13261-71
pubmed: 21257746
Mutat Res. 2011 May-Jun;727(3):86-103
pubmed: 21421074
PLoS One. 2011 Apr 27;6(4):e18910
pubmed: 21556138
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W38-44
pubmed: 21715387
Nucleic Acids Res. 1990 Oct 25;18(20):6097-100
pubmed: 2172928
Nature. 2011 Sep 04;477(7366):616-20
pubmed: 21892188
Lancet. 2011 Sep 10;378(9795):1006-14
pubmed: 21907864
PLoS One. 2012;7(2):e32138
pubmed: 22359664
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Nat Commun. 2012 Jun 06;3:878
pubmed: 22673905
Nat Rev Mol Cell Biol. 2012 Jun 20;13(7):411-24
pubmed: 22713970
Cell Mol Life Sci. 2013 May;70(9):1509-24
pubmed: 23455074
Nat Struct Mol Biol. 2013 Apr;20(4):508-14
pubmed: 23474712
Nat Struct Mol Biol. 2013 Apr;20(4):502-7
pubmed: 23474714
EMBO J. 2013 May 2;32(9):1225-37
pubmed: 23481255
FEBS J. 2013 Aug;280(15):3491-507
pubmed: 23711178
Nat Rev Mol Cell Biol. 2013 Jul;14(7):443-51
pubmed: 23736681
Nat Commun. 2013;4:2164
pubmed: 23917065
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W320-4
pubmed: 24753421
Nature. 2014 May 29;509(7502):575-81
pubmed: 24870542
PLoS One. 2014 Aug 14;9(8):e104998
pubmed: 25122211
Curr Protoc Bioinformatics. 2014 Sep 08;47:5.6.1-32
pubmed: 25199792
Nucleic Acids Res. 2015 Jan;43(Database issue):D447-52
pubmed: 25352553
Nat Commun. 2014 Dec 19;5:5887
pubmed: 25523213
Nat Methods. 2015 Jan;12(1):7-8
pubmed: 25549265
Cell Rep. 2015 Jan 13;10(2):148-61
pubmed: 25558065
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Nucleic Acids Res. 2015 Jul 1;43(W1):W30-8
pubmed: 25943547
Nat Protoc. 2015 Jun;10(6):845-58
pubmed: 25950237
Mol Neurobiol. 2017 Mar;54(2):997-1007
pubmed: 26797518
Annu Rev Biochem. 2016 Jun 2;85:431-54
pubmed: 26844395
CNS Neurol Disord Drug Targets. 2016;15(4):448-63
pubmed: 26996174
Am J Hum Genet. 2016 Apr 7;98(4):782-8
pubmed: 27040691
Nucleic Acids Res. 2016 Jul 8;44(W1):W242-5
pubmed: 27095192
Int J Oncol. 2016 Aug;49(2):646-56
pubmed: 27277835
Clin Genet. 2017 Jan;91(1):100-105
pubmed: 27311568
Mol Cell. 2016 Dec 15;64(6):1109-1116
pubmed: 27939941
FEBS J. 2017 Sep;284(18):2932-2946
pubmed: 28383827
Nucleic Acids Res. 2017 Jul 3;45(W1):W291-W299
pubmed: 28472402
Hum Genet. 2017 Nov;136(11-12):1419-1429
pubmed: 28940097
Front Immunol. 2017 Sep 19;8:1172
pubmed: 28974953
FEBS J. 2017 Dec;284(23):4002-4016
pubmed: 29054115
Nucleic Acids Res. 2018 Jan 4;46(D1):D246-D251
pubmed: 29165655
Chem Rev. 2018 Feb 14;118(3):1092-1136
pubmed: 29172462
Mol Cell. 2017 Dec 7;68(5):847-859.e7
pubmed: 29220652
Nucleic Acids Res. 2018 Mar 16;46(5):2417-2431
pubmed: 29361132
Nat Chem Biol. 2018 Feb 14;14(3):236-243
pubmed: 29443986
Drug Des Devel Ther. 2018 Feb 12;12:281-293
pubmed: 29483769
Front Cell Neurosci. 2018 Mar 21;12:72
pubmed: 29618972
Cell. 2018 Oct 18;175(3):809-821.e19
pubmed: 30270044
Cell Rep. 2018 Oct 9;25(2):437-448
pubmed: 30304683
Curr Opin Struct Biol. 2018 Dec;53:187-198
pubmed: 30481609
Comput Appl Biosci. 1993 Dec;9(6):745-56
pubmed: 8143162