The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause.
Animals
Antioxidants
/ metabolism
Biomarkers
/ analysis
Dietary Supplements
Disease Models, Animal
Fatty Acids, Omega-3
/ administration & dosage
Female
Heart
/ drug effects
Menopause
/ drug effects
Ovariectomy
/ veterinary
Oxidative Stress
/ drug effects
Rats
Rats, Wistar
Thioctic Acid
/ administration & dosage
Diet
heart
lipoic acid
menopause
oxidative stress
polyunsaturated fatty acid
Journal
Free radical research
ISSN: 1029-2470
Titre abrégé: Free Radic Res
Pays: England
ID NLM: 9423872
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
21
5
2019
medline:
21
12
2019
entrez:
21
5
2019
Statut:
ppublish
Résumé
Menopause occurs as consequence of ovarian senescence that leads to a drop of oestrogen hormone. The decreased oestrogen levels combined with the impairment of the redox system may contribute to the increased risk of postmenopausal cardiovascular disease. Supplementation with antioxidants may be an alternative to reduce cardiovascular risk. The study evaluated the effect of dietary supplementation with docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and α-lipoic acid (LA) for a period of 16 weeks on oxidative stress biomarkers in the hearts of ovariectomized 3-month-old rats. Ovariectomy did not increase the level of the damage markers malondialdehyde and carbonyl, and both were decreased by LA supplementation. Ovariectomy increased the levels of the endogenous antioxidants glutathione, vitamin C and H
Identifiants
pubmed: 31106614
doi: 10.1080/10715762.2019.1620938
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
Fatty Acids, Omega-3
0
Thioctic Acid
73Y7P0K73Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM