Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique.
Administration, Cutaneous
Adult
Anesthetics, Local
/ pharmacology
Cross-Over Studies
Double-Blind Method
Electric Stimulation
Electrodiagnosis
Female
Healthy Volunteers
Humans
Lidocaine, Prilocaine Drug Combination
/ pharmacology
Male
Nerve Fibers, Myelinated
/ drug effects
Nerve Fibers, Unmyelinated
/ drug effects
Sensory Thresholds
/ drug effects
Small Fiber Neuropathy
/ diagnosis
Young Adult
cutaneous analgesia
nerve fiber excitability
perception thresholds
pin electrode
quantitative sensory testing
small fiber neuropathy
threshold tracking
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
17
10
2018
revised:
14
05
2019
accepted:
14
05
2019
pubmed:
21
5
2019
medline:
15
1
2020
entrez:
21
5
2019
Statut:
ppublish
Résumé
Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. Small sensory fibers were selectively blocked by 120-minute topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength-duration relation and threshold electrotonus. The excitability assessed by the strength-duration relation and threshold electrotonus was significantly modulated for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers, suggesting the usefulness of the technique as a diagnostic method for assessing impairment of small fibers, as seen in many types of polyneuropathies.
Substances chimiques
Anesthetics, Local
0
Lidocaine, Prilocaine Drug Combination
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-375Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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