The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
Apoptosis
/ genetics
Breast Neoplasms
/ genetics
Calcium-Binding Proteins
/ genetics
Carcinogenesis
/ genetics
Cell Cycle
/ genetics
Cell Division
/ genetics
Cell Proliferation
/ genetics
Female
Gene Expression Regulation, Neoplastic
Humans
MCF-7 Cells
Membrane Proteins
/ genetics
RNA, Small Interfering
/ genetics
Receptors, Notch
/ genetics
Transfection
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
01
2019
accepted:
02
05
2019
entrez:
21
5
2019
pubmed:
21
5
2019
medline:
25
1
2020
Statut:
epublish
Résumé
These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.
Identifiants
pubmed: 31107884
doi: 10.1371/journal.pone.0217002
pii: PONE-D-19-02130
pmc: PMC6527237
doi:
Substances chimiques
Calcium-Binding Proteins
0
DLK1 protein, human
0
Membrane Proteins
0
RNA, Small Interfering
0
Receptors, Notch
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0217002Déclaration de conflit d'intérêts
The authors have the following interests: Ana Barbas is employed by Bayer Portugal. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
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