Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice.
Animals
Circadian Clocks
/ genetics
Circadian Rhythm
/ genetics
Corticosterone
/ metabolism
Female
Gene Expression
/ genetics
Gene Expression Regulation, Neoplastic
/ genetics
Hypothalamus
/ metabolism
Mammary Neoplasms, Animal
/ genetics
Mammary Neoplasms, Experimental
/ genetics
Mice
Mice, Inbred BALB C
Motor Activity
/ physiology
Cancer
Circadian
Corticosterone
Entrainment
Monocyte
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
02
2019
revised:
26
04
2019
accepted:
16
05
2019
pubmed:
21
5
2019
medline:
21
7
2020
entrez:
21
5
2019
Statut:
ppublish
Résumé
Circadian rhythms influence various aspects of biology, including hormonal, immunological, and behavioral processes. These 24-hour oscillations are necessary to optimize cellular functions and to synchronize these processes with the environment. Breast cancer patients and survivors frequently report disruptions in circadian oscillations that adversely affect quality-of-life, including fragmented sleep-wake cycles and flattened cortisol rhythms, which are associated with negative behavioral comorbidities (e.g., fatigue). However, the potential causal role of tumor biology in circadian dysregulation has not been investigated. Here, we examined the extent to which sham surgery, non-metastatic mammary tumors, or mammary tumor removal in mice disrupts circadian rhythms in brain clock gene expression, locomotor behavior (free-running and entrained), and physiological rhythms that have been associated with cancer behavioral comorbidities. Tumors and tumor resection altered time-of-day differences in hypothalamic expression of eight circadian-regulated genes. The onset of activity in entrained running behavior was advanced in tumor-bearing mice, and the amplitude of free-running rhythms was increased in tumor-resected mice. Tumors flattened rhythms in circulating corticosterone and Ly6c
Identifiants
pubmed: 31108169
pii: S0889-1591(19)30209-0
doi: 10.1016/j.bbi.2019.05.028
pmc: PMC6664435
mid: NIHMS1530448
pii:
doi:
Substances chimiques
Corticosterone
W980KJ009P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
805-817Subventions
Organisme : NCI NIH HHS
ID : R01 CA216290
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103361
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091302
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG058109
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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