Cases in Precision Medicine: The Role of Pharmacogenetics in Precision Prescribing.
Journal
Annals of internal medicine
ISSN: 1539-3704
Titre abrégé: Ann Intern Med
Pays: United States
ID NLM: 0372351
Informations de publication
Date de publication:
04 06 2019
04 06 2019
Historique:
pubmed:
21
5
2019
medline:
14
2
2020
entrez:
21
5
2019
Statut:
ppublish
Résumé
Pharmacogenetics may help physicians deliver individualized treatments based on how a person's genes affect a drug's effects and metabolism. This information can help prevent adverse events or improve drug efficacy by enabling the physician to optimize dosage or to avoid a medication with adverse reactions and to prescribe an alternative therapy. This article discusses the current clinical utility of pharmacogenetic testing in the context of a patient who requires anticoagulation with warfarin.
Identifiants
pubmed: 31108507
pii: 2734025
doi: 10.7326/M18-2357
pmc: PMC7458588
mid: NIHMS1618182
doi:
Substances chimiques
Anticoagulants
0
Warfarin
5Q7ZVV76EI
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
796-804Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Références
Pharmacogenet Genomics. 2015 Feb;25(2):73-81
pubmed: 25461246
N Engl J Med. 2013 Dec 12;369(24):2294-303
pubmed: 24251363
Am J Transplant. 2016 Jul;16(7):2085-96
pubmed: 26714287
Pharmgenomics Pers Med. 2016 Oct 14;9:107-116
pubmed: 27789970
N Engl J Med. 2009 Feb 19;360(8):753-64
pubmed: 19228618
Clin Pharmacol Ther. 2012 Oct;92(4):414-7
pubmed: 22992668
Annu Rev Pharmacol Toxicol. 2015;55:89-106
pubmed: 25292429
N Engl J Med. 2013 Dec 12;369(24):2283-93
pubmed: 24251361
Genet Med. 2019 May;21(5):1224-1232
pubmed: 31048813
Catheter Cardiovasc Interv. 2019 Jun 1;93(7):1246-1252
pubmed: 30403317
Clin Pharmacol Ther. 2017 Sep;102(3):397-404
pubmed: 28198005
Lancet. 2013 Aug 31;382(9894):790-6
pubmed: 23755828
Clin Pharmacol Ther. 2008 Sep;84(3):326-31
pubmed: 18305455
Br J Clin Pharmacol. 2015 Oct;80(4):868-77
pubmed: 25060532
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):56-67
pubmed: 24616371
Pharmacogenomics J. 2017 Oct;17(5):395-402
pubmed: 28607506
Clin Pharmacol Ther. 2017 Sep;102(3):502-510
pubmed: 28090649
Clin Pharmacol Ther. 2013 Aug;94(2):207-10
pubmed: 23588301
JAMA. 2017 Sep 26;318(12):1115-1124
pubmed: 28973620