Neutrophil-to-Lymphocyte Ratio in Rectal Cancer-Novel Biomarker of Tumor Immunogenicity During Radiotherapy or Confounding Variable?
Aged
Biomarkers, Tumor
/ blood
Chemoradiotherapy, Adjuvant
Disease-Free Survival
Female
Fluorouracil
/ administration & dosage
Humans
Lymphocyte Count
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Neutrophils
/ cytology
Predictive Value of Tests
Rectal Neoplasms
/ blood
Retrospective Studies
Treatment Outcome
inflammation
leukocytosis
neoadjuvant radiotherapy
neutrophil-to-lymphocyte ratio
pathologic response
rectal cancer
tumor volume
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 May 2019
17 May 2019
Historique:
received:
15
04
2019
revised:
10
05
2019
accepted:
13
05
2019
entrez:
22
5
2019
pubmed:
22
5
2019
medline:
13
11
2019
Statut:
epublish
Résumé
The aim of this study was to investigate the predictive value of blood-derived makers of local and systemic inflammatory responses on early and long-term oncological outcomes. A retrospective analysis of patients with locally advanced rectal cancer treated with preoperative long-course 5-fluorouracil-based radiochemotherapy was performed. Differential blood counts before neoadjuvant treatment were extracted from the patients' electronic charts. Optimal cut-off values for neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were determined. Potential clinical and hematological prognostic factors for disease-free survival (DFS) were studied using uni- and multivariate analysis. A total of 220 patients were included in the analysis. Median follow-up was 67 months. Five-year DFS and overall survival (OS) were 70% and 85%, respectively. NLR with a cut-off value of 4.06 was identified as optimal to predict DFS events. In multivariate analysis, only tumor volume (HR 0.33, 95% CI (0.14-0.83),
Identifiants
pubmed: 31108935
pii: ijms20102448
doi: 10.3390/ijms20102448
pmc: PMC6566677
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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