Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer.
EGFR
c-MET
cancer-associated fibroblasts
focal adhesion kinase
integrin
mechanotransduction
therapy resistance
tyrosine kinase inhibitors
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 May 2019
17 May 2019
Historique:
received:
15
04
2019
revised:
13
05
2019
accepted:
14
05
2019
entrez:
22
5
2019
pubmed:
22
5
2019
medline:
22
5
2019
Statut:
epublish
Résumé
Integrins contribute to cancer progression and aggressiveness by activating intracellular signal transduction pathways and transducing mechanical tension forces. Remarkably, these adhesion receptors share common signaling networks with receptor tyrosine kinases (RTKs) and support their oncogenic activity, thereby promoting cancer cell proliferation, survival and invasion. During the last decade, preclinical studies have revealed that integrins play an important role in resistance to therapies targeting RTKs and their downstream pathways. A remarkable feature of integrins is their wide-ranging interconnection with RTKs, which helps cancer cells to adapt and better survive therapeutic treatments. In this context, we should consider not only the integrins expressed in cancer cells but also those expressed in stromal cells, since these can mechanically increase the rigidity of the tumor microenvironment and confer resistance to treatment. This review presents some of these mechanisms and outlines new treatment options for improving the efficacy of therapies targeting RTK signaling.
Identifiants
pubmed: 31109009
pii: cancers11050692
doi: 10.3390/cancers11050692
pmc: PMC6562376
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ligue Contre le Cancer
ID : Grand Est Bourgogne Franche-Comté - CCIR Est
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