Titanium dioxide nanoparticles induce endothelial cell apoptosis via cell membrane oxidative damage and p38, PI3K/Akt, NF-κB signaling pathways modulation.
Apoptosis
/ drug effects
Cell Membrane
/ drug effects
Cell Survival
/ drug effects
Endothelial Cells
/ drug effects
Humans
Lipid Peroxidation
MAP Kinase Signaling System
/ drug effects
Membrane Potential, Mitochondrial
/ drug effects
Metal Nanoparticles
/ chemistry
NF-kappa B
/ metabolism
Oxidation-Reduction
/ drug effects
Oxidative Stress
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Titanium
/ chemistry
Apoptosis
Cell membrane
Endothelial cell
Oxidative stress
Signaling pathways
Titanium dioxide nanoparticles
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
01
01
2019
revised:
27
02
2019
accepted:
22
03
2019
entrez:
22
5
2019
pubmed:
22
5
2019
medline:
22
11
2019
Statut:
ppublish
Résumé
Titanium dioxide nanoparticles (TiO In the present study, we conducted an in vitro study to re-evaluate the possible toxic effects of TiO Our results demonstrated that, TiO Taken together, this study confirmed the effects of TiO
Sections du résumé
BACKGROUND
BACKGROUND
Titanium dioxide nanoparticles (TiO
METHODS
METHODS
In the present study, we conducted an in vitro study to re-evaluate the possible toxic effects of TiO
RESULTS
RESULTS
Our results demonstrated that, TiO
CONCLUSIONS
CONCLUSIONS
Taken together, this study confirmed the effects of TiO
Identifiants
pubmed: 31109618
pii: S0946-672X(19)30003-3
doi: 10.1016/j.jtemb.2019.03.008
pii:
doi:
Substances chimiques
NF-kappa B
0
Reactive Oxygen Species
0
titanium dioxide
15FIX9V2JP
Titanium
D1JT611TNE
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-35Informations de copyright
Copyright © 2019. Published by Elsevier GmbH.