A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas.

Animals Bacterial Adhesion Bacterial Proteins / immunology Biofilms Chinchilla Female Fimbriae Proteins / immunology Haemophilus Vaccines / immunology Haemophilus influenzae / immunology Immunization Mice Mice, Inbred BALB C Nasopharynx / microbiology Otitis Media / prevention & control Vaccines, Synthetic / immunology Vitronectin / metabolism
Haemophilus influenzae PilA chinchilla mouse protein E vaccines

Journal

Infection and immunity
ISSN: 1098-5522
Titre abrégé: Infect Immun
Pays: United States
ID NLM: 0246127

Informations de publication

Date de publication:
08 2019
Historique:
received: 10 05 2019
accepted: 10 05 2019
pubmed: 22 5 2019
medline: 27 11 2019
entrez: 22 5 2019
Statut: epublish

Résumé

PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the majority subunit of the type IV pilus (PilA), two major antigens of nontypeable

Identifiants

DOI: 10.1128/IAI.00345-19 PMID: 31109946 PMC: PMC6652774
pubmed: 31109946
pii: IAI.00345-19
doi: 10.1128/IAI.00345-19
pmc: PMC6652774
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Haemophilus Vaccines 0
Vaccines, Synthetic 0
Vitronectin 0
Fimbriae Proteins 147680-16-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 Ysebaert et al.

Références

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Auteurs

Carine Ysebaert (C)

GSK, Rixensart, Belgium.

Philippe Denoël (P)

GSK, Rixensart, Belgium.

Vincent Weynants (V)

GSK, Rixensart, Belgium.

Lauren O Bakaletz (LO)

Department of Pediatrics, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.

Laura A Novotny (LA)

Department of Pediatrics, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.

Fabrice Godfroid (F)

GSK, Rixensart, Belgium.

Philippe Hermand (P)

GSK, Rixensart, Belgium philippe.hermand@gsk.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques bactériens › Adhérence bactérienne › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Chinchilla › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de la membrane externe bactérienne › Protéines de fimbriae › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Vaccins anti-Haemophilus › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pasteurellaceae › Haemophilus › Haemophilus influenzae › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Système stomatognathique › Pharynx › Partie nasale du pharynx › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies des oreilles › Otite › Otite moyenne › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › A Protein E-PilA Fusion Protein Shows Vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Vitronectine › A Protein E-PilA Fusion Protein Shows Vaccine...