Synapsins regulate α-synuclein functions.

Animals Cell Line Mice Neurons / metabolism Synapses / metabolism Synapsins / metabolism Synaptic Vesicles / metabolism alpha-Synuclein / metabolism
alpha synuclein neurotransmission synapsin

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
04 06 2019
Historique:
pubmed: 22 5 2019
medline: 26 3 2020
entrez: 22 5 2019
Statut: ppublish

Résumé

The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

Identifiants

DOI: 10.1073/pnas.1903054116 PMID: 31110014 PMC: PMC6561288
pubmed: 31110014
pii: 1903054116
doi: 10.1073/pnas.1903054116
pmc: PMC6561288
doi:

Substances chimiques

Synapsins 0
alpha-Synuclein 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11116-11118

Subventions

Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048218
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111978
Pays : United States

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

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Auteurs

Merav Atias (M)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.

Yaara Tevet (Y)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.

Jichao Sun (J)

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705.

Alexandra Stavsky (A)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.

Shani Tal (S)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.

Joy Kahn (J)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.

Subhojit Roy (S)

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705; gitler@bgu.ac.il roy27@wisc.edu.
Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705.
ORCID: 0000-0002-1571-2735

Daniel Gitler (D)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel; gitler@bgu.ac.il roy27@wisc.edu.
Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
ORCID: 0000-0001-9544-3610

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Cellules › Neurones › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Synapsine › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Vésicules synaptiques › Synapsins regulate α-synuclein functions.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Synapsins regulate α-synuclein functions.