Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling.
Parkinson’s disease
alpha synuclein
synaptic transmission
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
04 06 2019
04 06 2019
Historique:
pubmed:
22
5
2019
medline:
26
3
2020
entrez:
22
5
2019
Statut:
ppublish
Résumé
The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone-but with no effect on neurotransmission-while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.
Identifiants
pubmed: 31110017
pii: 1903049116
doi: 10.1073/pnas.1903049116
pmc: PMC6561242
doi:
Substances chimiques
SNARE Proteins
0
SNCA protein, human
0
VAMP2 protein, human
0
Vesicle-Associated Membrane Protein 2
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
11113-11115Subventions
Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048218
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111978
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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