Early Social Stress Promotes Inflammation and Disease Risk in Rhesus Monkeys.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 05 2019
20 05 2019
Historique:
received:
22
02
2019
accepted:
29
04
2019
entrez:
22
5
2019
pubmed:
22
5
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Early social stress has potent lifelong health effects. We examined the association of early stress in the attachment relationship (low maternal sensitivity, low MS), lower maternal social hierarchy rank, and greater frequency of group-level social conflict, with biomarkers of inflammatory stress response in plasma (IL-8, MCP-1 and CRP collected two hours after temporary separation from mothers and social groups) and risk for developing a common macaques disease outcome (infectious colitis) in 170 socially-housed rhesus monkeys. We controlled for gene-environment correlations by comparing cross-fostered subjects with infants reared by their biological mothers. Low MS predicted higher levels of pro-inflammatory cytokines and proteins at 3-4 months of age (F(3, 162) = 3.508, p = 0.002, partial eta
Identifiants
pubmed: 31110226
doi: 10.1038/s41598-019-43750-1
pii: 10.1038/s41598-019-43750-1
pmc: PMC6527690
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
7609Subventions
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD069600
Pays : United States
Organisme : NIH HHS
ID : R24 OD010962
Pays : United States
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