Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation.
Action Potentials
Adult
Aged
Aged, 80 and over
Atrial Fibrillation
/ diagnosis
Atrial Function, Left
Atrial Remodeling
Catheter Ablation
/ adverse effects
Computer Simulation
Female
Heart Rate
Humans
Male
Middle Aged
Models, Cardiovascular
Prospective Studies
Pulmonary Veins
/ physiopathology
Recurrence
Refractory Period, Electrophysiological
Time Factors
Treatment Outcome
Wavelet Analysis
atrial fibrillation vulnerability
conduction velocity
left atrial effective conducting size
refractoriness
Journal
Journal of cardiovascular electrophysiology
ISSN: 1540-8167
Titre abrégé: J Cardiovasc Electrophysiol
Pays: United States
ID NLM: 9010756
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
04
02
2019
revised:
01
05
2019
accepted:
17
05
2019
pubmed:
22
5
2019
medline:
15
9
2020
entrez:
22
5
2019
Statut:
ppublish
Résumé
The multiple wavelets and functional re-entry hypotheses are mechanistic theories to explain atrial fibrillation (AF). If valid, a chamber's ability to support AF should depend upon the left atrial size, conduction velocity (CV), and refractoriness. Measurement of these parameters could provide a new therapeutic target for AF. We investigated the relationship between left atrial effective conducting size (LA Activation mapping was performed in patients with paroxysmal (n = 21) and persistent AF (n = 18) undergoing pulmonary vein isolation. Parameters used for calculating LA LA
Sections du résumé
BACKGROUND
The multiple wavelets and functional re-entry hypotheses are mechanistic theories to explain atrial fibrillation (AF). If valid, a chamber's ability to support AF should depend upon the left atrial size, conduction velocity (CV), and refractoriness. Measurement of these parameters could provide a new therapeutic target for AF. We investigated the relationship between left atrial effective conducting size (LA
METHODS AND RESULTS
Activation mapping was performed in patients with paroxysmal (n = 21) and persistent AF (n = 18) undergoing pulmonary vein isolation. Parameters used for calculating LA
CONCLUSIONS
LA
Identifiants
pubmed: 31111557
doi: 10.1111/jce.13990
pmc: PMC6746623
mid: EMS84280
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1416-1427Subventions
Organisme : British Heart Foundation
ID : WT 203148/Z/16/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/13/37/30280
Pays : United Kingdom
Organisme : Medical Research Council UK
ID : MR/N001877/1
Pays : International
Organisme : British Heart Foundation
ID : FS/18/27/33543
Pays : United Kingdom
Organisme : Medical Research Council UK Clinical Research Training Fellowship
ID : MR/N001877/1Disclosures: None.
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2019 The Authors Journal of Cardiovascular ElectrophysiologyPublished by Wiley Periodicals, Inc.
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