Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-β Signaling Pathway and Interaction With Histone Acetylation.
Acetylation
Animals
Cell Differentiation
Core Binding Factor Alpha 1 Subunit
/ biosynthesis
Dental Pulp
/ cytology
Extracellular Matrix Proteins
/ biosynthesis
Gene Expression Regulation
Histone Deacetylase 2
/ biosynthesis
Histones
/ genetics
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors
/ genetics
Mice
Mice, Knockout
Odontoblasts
/ cytology
Sp7 Transcription Factor
/ biosynthesis
Transcription, Genetic
Transforming Growth Factor beta
/ genetics
DENTINOGENESIS
Dmp1
HISTONE ACETYLATION
Klf4
Sp7
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
16
12
2018
revised:
04
03
2019
accepted:
05
03
2019
pubmed:
22
5
2019
medline:
14
8
2020
entrez:
22
5
2019
Statut:
ppublish
Résumé
Transcription factors bind to cell-specific cis-regulatory elements, such as enhancers and promoters, to initiate much of the gene expression program of different biological process. Odontoblast differentiation is a necessary step for tooth formation and is also governed by a complex gene regulatory network. Our previous in vitro experiments showed that Krüppel-like factor 4 (KLF4) can promote odontoblastic differentiation of both mouse dental papillary cells (mDPCs) and human dental pulp cells; however, its mechanism remains unclear. We first used Wnt1-Cre; KLF4
Identifiants
pubmed: 31112333
doi: 10.1002/jbmr.3716
pmc: PMC8895434
mid: NIHMS1069229
doi:
Substances chimiques
Core Binding Factor Alpha 1 Subunit
0
Dmp1 protein, mouse
0
Extracellular Matrix Proteins
0
Histones
0
KLF4 protein, human
0
Klf4 protein, mouse
0
Kruppel-Like Factor 4
0
Kruppel-Like Transcription Factors
0
Runx2 protein, mouse
0
Sp7 Transcription Factor
0
Sp7 protein, mouse
0
Transforming Growth Factor beta
0
Hdac2 protein, mouse
EC 3.5.1.98
Histone Deacetylase 2
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1502-1516Subventions
Organisme : National Natural Science Foundation of China
ID : 81771057
Pays : International
Organisme : NIDCR NIH HHS
ID : R01 DE019802
Pays : United States
Organisme : CAST
ID : 2017QNRC001
Pays : International
Organisme : Natural Science Foundation of Hubei Province
ID : 2017CFB515
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81420108011
Pays : International
Organisme : Young Elite Scientist Sponsorship Program by CAST
ID : 2017QNRC001
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81271099
Pays : International
Informations de copyright
© 2019 American Society for Bone and Mineral Research.
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