Shedding light on coatings: Real-time monitoring of coating quality at industrial scale.
Coating quality
Coating thickness
In-line monitoring
Optical coherence tomography
Quality assurance
Real-time release
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
20 Jul 2019
20 Jul 2019
Historique:
received:
15
01
2019
revised:
17
05
2019
accepted:
17
05
2019
pubmed:
22
5
2019
medline:
18
12
2019
entrez:
22
5
2019
Statut:
ppublish
Résumé
Optical Coherence Tomography (OCT) is increasingly being used for studies of pharmaceutical film coating. OCT allows fast and non-destructive analysis of the coating thickness and quality via high-resolution cross-sectional images. Information about both the coating thickness and the coating quality can be extracted. Most studies and OCT applications performed to date have been limited to off-line measurements and off-line computations of coating features based on data acquired in-line. This study examines OCT's applicability to an industrial-scale pan coating process. Automated layer detection, classification and thickness calculation were executed in real time. To evaluate the system's performance, runs with various tablet size, coating solution concentration and operating parameters were carried out and monitored. Our results indicate that, in addition to correct end-point determination, OCT enables real-time monitoring of the coating processes (thickness, homogeneity and roughness) and can support active process control by supplying information about the coating thickness and quality.
Identifiants
pubmed: 31112796
pii: S0378-5173(19)30407-7
doi: 10.1016/j.ijpharm.2019.05.048
pii:
doi:
Substances chimiques
Kollicoat IR
0
Polyvinyls
0
Tablets, Enteric-Coated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-66Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.