Cytotoxic lignans from the stems of Herpetospermum pedunculosum.

Antineoplastic Agents, Phytogenic / chemistry Cell Line, Tumor Cell Proliferation / drug effects Cucurbitaceae / chemistry Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Lignans / chemistry Molecular Conformation Plant Stems / chemistry Structure-Activity Relationship
Cytotoxicity Herpetosiols A-F Herpetospermum pedunculosum (cucurbitaceae) Lignans

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 13 09 2018
revised: 07 05 2019
accepted: 07 05 2019
pubmed: 22 5 2019
medline: 7 8 2019
entrez: 22 5 2019
Statut: ppublish

Résumé

A bioassay-guided chemical investigation on the ethyl acetate extract of the stems of Herpetospermum pedunculosum led to the isolation and identification of 22 lignans including 6 previously undescribed ones, herpetosiols A-F. Their structures including stereochemistries were elucidated by analysis of NMR, HRMS and ECD data. The in vitro cytotoxic activities of all isolates were studied against human gastric carcinoma SGC7901, lung carcinoma A549, breast carcinoma MDA-MB-231 and hepatocellular carcinoma HepG2 cell lines. Among them, eight lignans exhibited anti-proliferative effects against four tumor cell lines with IC

Identifiants

DOI: 10.1016/j.phytochem.2019.05.004 PMID: 31112925
pubmed: 31112925
pii: S0031-9422(18)30318-2
doi: 10.1016/j.phytochem.2019.05.004
pii:
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Lignans 0

Types de publication

Journal Article

Langues

eng

Pagination

102-110

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Yingxiong Ma (Y)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China.

Hong Wang (H)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China.

Rui Wang (R)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China.

Fancheng Meng (F)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China.

Zhaoyue Dong (Z)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China.

Guowei Wang (G)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China.

Xiaozhong Lan (X)

TAAHC-SWU Medicinal Plant R&D Center, XiZang Agriculture and Animal Husbandry College, Nyingchi, Tibet, 860000, PR China.

Hong Quan (H)

TAAHC-SWU Medicinal Plant R&D Center, XiZang Agriculture and Animal Husbandry College, Nyingchi, Tibet, 860000, PR China. Electronic address: xiaozhonglan2003@tom.com.

Zhihua Liao (Z)

School of Life Sciences, Southwest University, Chongqing, 400715, PR China.

Min Chen (M)

College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), Southwest University, Chongqing, 400715, PR China. Electronic address: mminchen@swu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Cucurbitaceae › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Lignanes › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Tiges de plante › Cytotoxic lignans from the stems of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Cytotoxic lignans from the stems of...