Quantitative Analysis of Retinal Microvascular Changes after Conbercept Therapy in Branch Retinal Vein Occlusion Using Optical Coherence Tomography Angiography.
Capillaries
/ diagnostic imaging
Choroid
/ diagnostic imaging
Female
Fluorescein Angiography
/ methods
Follow-Up Studies
Fundus Oculi
Humans
Male
Microcirculation
/ drug effects
Middle Aged
Recombinant Fusion Proteins
/ administration & dosage
Retinal Vein Occlusion
/ diagnosis
Retinal Vessels
/ diagnostic imaging
Retrospective Studies
Tomography, Optical Coherence
/ methods
Treatment Outcome
Visual Acuity
Branch retinal vein occlusion
Conbercept
Macular oedema
Optical coherence tomography angiography
Journal
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
ISSN: 1423-0267
Titre abrégé: Ophthalmologica
Pays: Switzerland
ID NLM: 0054655
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
11
2018
accepted:
14
03
2019
pubmed:
22
5
2019
medline:
10
8
2019
entrez:
22
5
2019
Statut:
ppublish
Résumé
To quantitatively evaluate microvascular changes in eyes with macular oedema due to branch retinal vein occlusion (BRVO) using optical coherence tomography angiography (OCTA) before and after intravitreal conbercept injection and the correlation of such changes with best-corrected visual acuity (BCVA) and retinal thickness. Twenty-eight eyes of 28 patients treated with a single intravitreal injection of conbercept for macular oedema due to BRVO were included in this study. The automatically measured values of the vessel density in the superficial (SCP) and deep retinal capillary plexus (DCP), the foveal avascular zone (FAZ) area, the FAZ perimeter, the vessel density within a 300 μm wide ring surrounding the FAZ (FD-300), the acircularity index (AI), the choriocapillaris flow area and the retinal thickness were obtained via OCTA before and at 1 month after initial injection and compared with those of age- and sex- matched healthy subjects. In BRVO eyes, the vascular density in the SCP and DCP, the FD-300 and the flow area of choriocapillaris were significantly lower than those in healthy eyes, while the AI and the retinal thickness were significantly increased. After treatment, the retinal thickness in eyes with BRVO was significantly decreased in all quadrants, and the mean BCVA dramatically increased from 20/162 to 20/78 (p = 0.0017). The mean flow area of choriocapillaris significantly improved after treatment. Moreover, negative correlations between the logMAR BCVA and the whole vascular density in the SCP and DCP as well as the flow area of choriocapillaris were observed. OCTA enables non-invasive, layer-specific and quantitative assessment of microvascular changes in eyes with BRVO before and after treatment, and it can be used as a valuable imaging tool for the evaluation of the follow-up in BRVO patients.
Identifiants
pubmed: 31112969
pii: 000499608
doi: 10.1159/000499608
doi:
Substances chimiques
Recombinant Fusion Proteins
0
KH902 fusion protein
1P05PW62F3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-80Informations de copyright
© 2019 S. Karger AG, Basel.