The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury.
Animals
Antigens, CD
/ genetics
Antigens, Differentiation, Myelomonocytic
/ genetics
B7-2 Antigen
/ genetics
Lectins, C-Type
/ genetics
Locomotion
Low-Level Light Therapy
/ methods
Male
Mannose Receptor
Mannose-Binding Lectins
/ genetics
Rats
Rats, Wistar
Receptors, Cell Surface
/ genetics
Spinal Cord
/ metabolism
Spinal Cord Injuries
/ therapy
Spinal Cord Regeneration
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 05 2019
21 05 2019
Historique:
received:
09
08
2018
accepted:
08
05
2019
entrez:
23
5
2019
pubmed:
23
5
2019
medline:
21
10
2020
Statut:
epublish
Résumé
We investigated the effect of a Multiwave Locked System laser (with a simultaneous 808 nm continuous emission and 905 nm pulse emission) on the spinal cord after spinal cord injury (SCI) in rats. The functional recovery was measured by locomotor tests (BBB, Beam walking, MotoRater) and a sensitivity test (Plantar test). The locomotor tests showed a significant improvement of the locomotor functions of the rats after laser treatment from the first week following lesioning, compared to the controls. The laser treatment significantly diminished thermal hyperalgesia after SCI as measured by the Plantar test. The atrophy of the soleus muscle was reduced in the laser treated rats. The histopathological investigation showed a positive effect of the laser therapy on white and gray matter sparing. Our data suggests an upregulation of M2 macrophages in laser treated animals by the increasing number of double labeled CD68+/CD206+ cells in the cranial and central parts of the lesion, compared to the control animals. A shift in microglial/macrophage polarization was confirmed by gene expression analysis by significant mRNA downregulation of Cd86 (marker of inflammatory M1), and non-significant upregulation of Arg1 (marker of M2). These results demonstrated that the combination of 808 nm and 905 nm wavelength light is a promising non-invasive therapy for improving functional recovery and tissue sparing after SCI.
Identifiants
pubmed: 31113985
doi: 10.1038/s41598-019-44141-2
pii: 10.1038/s41598-019-44141-2
pmc: PMC6529518
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
B7-2 Antigen
0
CD68 antigen, human
0
Lectins, C-Type
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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