A Metabolism Toolbox for CAR T Therapy.
anti-tumor immune response
chimeric antigen receptor (CAR)
immunotherapy
metabolism
tumor microenvironment (TME)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
01
2019
accepted:
10
04
2019
entrez:
23
5
2019
pubmed:
23
5
2019
medline:
23
5
2019
Statut:
epublish
Résumé
The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) through genetic engineering is one of the most promising new therapies for treating cancer patients. A robust CAR T cell-mediated anti-tumor response requires the coordination of nutrient and energy supplies with CAR T cell expansion and function. However, the high metabolic demands of tumor cells compromise the function of CAR T cells by competing for nutrients within the tumor microenvironment (TME). To substantially improve clinical outcomes of CAR T immunotherapy while treating solid tumors, it is essential to metabolically prepare CAR T cells to overcome the metabolic barriers imposed by the TME. In this review, we discuss a potential metabolism toolbox to improve the metabolic fitness of CAR T cells and maximize the efficacy of CAR T therapy.
Identifiants
pubmed: 31114756
doi: 10.3389/fonc.2019.00322
pmc: PMC6503740
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
322Subventions
Organisme : NIAID NIH HHS
ID : R01 AI114581
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA232488
Pays : United States
Références
Cancer Res. 1999 Dec 1;59(23):5863-70
pubmed: 10606224
N Engl J Med. 1975 Apr 3;292(14):714-9
pubmed: 1089883
Zhonghua Zhong Liu Za Zhi. 1997 May;19(3):188-91
pubmed: 10920893
Transplant Proc. 2001 Feb-Mar;33(1-2):677-9
pubmed: 11267013
Nat Immunol. 2001 Apr;2(4):307-15
pubmed: 11276201
Cancer Lett. 2001 Oct 30;172(2):177-85
pubmed: 11566494
J Immunol. 2001 Dec 15;167(12):6869-76
pubmed: 11739504
J Exp Med. 2002 Jan 7;195(1):59-70
pubmed: 11781366
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1491-6
pubmed: 11792859
Isr J Med Sci. 1979 Nov;15(11):925-7
pubmed: 118945
J Biol Chem. 2002 Aug 23;277(34):30409-12
pubmed: 12087111
Immunity. 2002 Jun;16(6):769-77
pubmed: 12121659
J Pediatr Hematol Oncol. 2003 May;25(5):414-7
pubmed: 12759631
Clin Cancer Res. 2003 Jun;9(6):1957-71
pubmed: 12796357
J Biol Chem. 2003 Nov 21;278(47):47110-8
pubmed: 12937174
Biochim Biophys Acta. 1953 Mar;10(3):414-26
pubmed: 13058999
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683
Prensa Med Argent. 1956 Feb 3;43(5):448-50
pubmed: 13335766
Chem Biol. 2003 Dec;10(12):1173-81
pubmed: 14700625
Annu Rev Immunol. 2004;22:745-63
pubmed: 15032595
J Physiol. 2004 Jul 1;558(Pt 1):5-30
pubmed: 15131240
Immunity. 2004 Jul;21(1):19-30
pubmed: 15345217
J Nutr. 2004 Oct;134(10 Suppl):2837S-2841S; discussion 2853S
pubmed: 15465796
J Clin Invest. 2005 Jun;115(6):1616-26
pubmed: 15931392
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9571-6
pubmed: 15980149
Nat Rev Immunol. 2005 Sep;5(9):712-21
pubmed: 16110315
Nat Clin Pract Oncol. 2005 Feb;2(2):108-13
pubmed: 16264883
Curr Top Med Chem. 2005;5(13):1259-74
pubmed: 16305530
J Exp Biol. 2005 Dec;208(Pt 24):4561-75
pubmed: 16326938
Crit Rev Clin Lab Sci. 2006;43(2):143-81
pubmed: 16517421
Nat Rev Drug Discov. 2006 Mar;5(3):247-64
pubmed: 16518376
Novartis Found Symp. 2006;276:26-48; discussion 48-57, 275-81
pubmed: 16805422
Transplantation. 1990 Feb;49(2):251-7
pubmed: 1689516
Nat Rev Cancer. 2006 Sep;6(9):729-34
pubmed: 16915295
Blood. 2007 Feb 15;109(4):1568-73
pubmed: 17023580
Oncogene. 2006 Oct 16;25(48):6373-83
pubmed: 17041623
Blood. 2007 May 1;109(9):3812-9
pubmed: 17255361
J Clin Invest. 2007 May;117(5):1147-54
pubmed: 17476344
J Dtsch Dermatol Ges. 2007 Aug;5(8):716-7
pubmed: 17659047
Nat Rev Mol Cell Biol. 2007 Oct;8(10):813-24
pubmed: 17848967
J Immunol. 2008 Apr 1;180(7):4476-86
pubmed: 18354169
Curr Pharm Des. 2008;14(11):1049-57
pubmed: 18473854
Nat Rev Drug Discov. 2008 Jul;7(7):575-90
pubmed: 18591979
Cell. 2008 Jul 11;134(1):97-111
pubmed: 18614014
Cell. 2008 Sep 5;134(5):703-7
pubmed: 18775299
Trends Neurosci. 2009 Jan;32(1):19-29
pubmed: 19008000
J Clin Invest. 2008 Dec;118(12):3930-42
pubmed: 19033663
Histol Histopathol. 2009 Feb;24(2):243-64
pubmed: 19085840
J Exp Med. 2009 Jan 16;206(1):43-9
pubmed: 19114668
N Engl J Med. 2009 Jan 29;360(5):447-58
pubmed: 19179314
J Immunol. 2009 Feb 15;182(4):2476-84
pubmed: 19201903
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Nat Rev Cancer. 2009 Jun;9(6):445-52
pubmed: 19461669
Nat Rev Drug Discov. 2009 Jul;8(7):579-91
pubmed: 19478820
Nature. 2009 Jul 2;460(7251):103-7
pubmed: 19494812
Immunity. 2009 Jun 19;30(6):832-44
pubmed: 19538929
Radiother Oncol. 2009 Sep;92(3):329-33
pubmed: 19604589
Nat Rev Cancer. 2009 Aug;9(8):563-75
pubmed: 19629071
Int J Biochem Cell Biol. 2010 Jan;42(1):39-51
pubmed: 19643201
Nat Rev Immunol. 2009 Sep;9(9):609-17
pubmed: 19704417
Nat Rev Cancer. 2009 Oct;9(10):691-700
pubmed: 19759539
Cell Cycle. 2009 Dec;8(23):3984-4001
pubmed: 19923890
Oncogene. 2010 Feb 4;29(5):625-34
pubmed: 19946328
J Immunol. 2010 Feb 1;184(3):1200-9
pubmed: 20026743
Cancer Res. 2010 Jan 1;70(1):68-77
pubmed: 20028852
Organogenesis. 2009 Jul;5(3):90-6
pubmed: 20046670
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7461-6
pubmed: 20351271
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60
pubmed: 20378837
Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):466-70
pubmed: 20473153
J Natl Cancer Inst. 2010 Jul 7;102(13):932-41
pubmed: 20513808
J Immunol. 2010 Jul 15;185(2):1037-44
pubmed: 20554958
Oncogene. 2010 Sep 30;29(39):5346-58
pubmed: 20661219
J Immunol. 2010 Sep 15;185(6):3190-8
pubmed: 20720200
Nat Rev Mol Cell Biol. 2010 Oct;11(10):688-99
pubmed: 20861879
Nitric Oxide. 2011 Jan 1;24(1):1-7
pubmed: 20933602
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19961-6
pubmed: 21041655
Genes Dev. 2010 Dec 15;24(24):2784-99
pubmed: 21106670
Curr Treat Options Oncol. 2010 Dec;11(3-4):107-17
pubmed: 21128029
Nat Rev Immunol. 2011 Feb;11(2):109-17
pubmed: 21233853
Nat Rev Cancer. 2011 Feb;11(2):85-95
pubmed: 21258394
J Mol Med (Berl). 2011 Mar;89(3):213-20
pubmed: 21301796
J Immunol. 2011 Mar 15;186(6):3299-303
pubmed: 21317389
Nat Rev Immunol. 2011 Mar;11(3):201-12
pubmed: 21331080
J Cachexia Sarcopenia Muscle. 2010 Sep;1(1):9-21
pubmed: 21475693
Science. 2011 Jul 8;333(6039):233-8
pubmed: 21680814
J Exp Med. 2011 Jul 4;208(7):1367-76
pubmed: 21708926
Biochim Biophys Acta. 2011 Nov;1807(11):1432-43
pubmed: 21771581
PLoS Genet. 2011 Aug;7(8):e1002229
pubmed: 21852960
Cell. 2011 Sep 2;146(5):772-84
pubmed: 21871655
Nat Cell Biol. 2011 Sep 02;13(9):1016-23
pubmed: 21892142
Cancer Cell. 2011 Sep 13;20(3):370-83
pubmed: 21907927
J Immunol. 2011 Oct 15;187(8):4187-98
pubmed: 21930968
Nature. 2011 Oct 05;478(7368):197-203
pubmed: 21976023
Annu Rev Cell Dev Biol. 2011;27:441-64
pubmed: 21985671
Nat Med. 2011 Oct 30;17(11):1498-503
pubmed: 22037646
N Engl J Med. 2011 Nov 3;365(18):1673-83
pubmed: 22047558
Nat Med. 2011 Nov 07;17(11):1359-70
pubmed: 22064426
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Immunity. 2012 Jan 27;36(1):68-78
pubmed: 22206904
Cell Signal. 2012 May;24(5):981-90
pubmed: 22286106
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2497-502
pubmed: 22308364
Trends Immunol. 2012 Apr;33(4):168-73
pubmed: 22342741
Sci Rep. 2012;2:266
pubmed: 22355778
Curr Pharm Des. 2012;18(10):1319-30
pubmed: 22360558
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
pubmed: 22436748
Cancer Cell. 2012 Mar 20;21(3):297-308
pubmed: 22439925
Cell. 2012 Mar 30;149(1):22-35
pubmed: 22464321
Nat Rev Immunol. 2012 Apr 20;12(5):325-38
pubmed: 22517423
Semin Oncol. 2012 Jun;39(3):323-39
pubmed: 22595055
F1000 Biol Rep. 2012;4:9
pubmed: 22615715
Recent Pat Anticancer Drug Discov. 2013 Jan 1;8(1):85-99
pubmed: 22738122
Oncoimmunology. 2012 Jul 1;1(4):458-466
pubmed: 22754764
Cancer Res. 2012 Oct 1;72(19):5130-40
pubmed: 22850421
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a008763
pubmed: 22952396
Nat Immunol. 2012 Oct;13(10):907-15
pubmed: 22990888
N Engl J Med. 2012 Sep 20;367(12):1087-97
pubmed: 22992072
N Engl J Med. 2012 Sep 20;367(12):1098-107
pubmed: 22992073
Nat Rev Cancer. 2012 Oct;12(10):671-84
pubmed: 22996603
Cancer Res. 2012 Nov 1;72(21):5435-40
pubmed: 23090118
Mol Cell. 2012 Oct 26;48(2):158-67
pubmed: 23102266
Cancer Res. 2012 Nov 15;72(22):5649-57
pubmed: 23144293
J Exp Med. 2012 Dec 17;209(13):2441-53
pubmed: 23183047
N Engl J Med. 2012 Dec 13;367(24):2322-33
pubmed: 23234515
Cancer Res. 2013 Mar 1;73(5):1524-35
pubmed: 23288510
Annu Rev Immunol. 2013;31:259-83
pubmed: 23298210
Nature. 2013 Jan 17;493(7432):346-55
pubmed: 23325217
Nature. 2013 Jan 31;493(7434):689-93
pubmed: 23334421
Cell Immunol. 2012 Dec;280(2):182-90
pubmed: 23399839
Nature. 2013 Apr 25;496(7446):513-7
pubmed: 23467085
Nature. 2013 Apr 25;496(7446):518-22
pubmed: 23467095
N Engl J Med. 2013 Apr 18;368(16):1509-1518
pubmed: 23527958
Nat Immunol. 2013 May;14(5):489-99
pubmed: 23563690
Int Immunol. 2013 Jun;25(6):335-43
pubmed: 23580432
Immunity. 2013 Apr 18;38(4):633-43
pubmed: 23601682
Trends Mol Med. 2013 Jun;19(6):355-67
pubmed: 23601906
Cancer Res. 2013 May 15;73(10):2929-35
pubmed: 23644529
Cold Spring Harb Perspect Med. 2013 Aug 01;3(8):null
pubmed: 23906881
J Clin Invest. 2013 Sep;123(9):3678-84
pubmed: 23999442
Nat Immunol. 2013 Oct;14(10):1014-22
pubmed: 24048123
Nat Immunol. 2013 Nov;14(11):1155-65
pubmed: 24056747
J Clin Invest. 2013 Oct;123(10):4479-88
pubmed: 24091329
Science. 2013 Oct 11;342(6155):1242454
pubmed: 24115444
J Exp Bot. 2014 Mar;65(5):1285-96
pubmed: 24218329
Annu Rev Med. 2014;65:333-47
pubmed: 24274181
Nat Rev Drug Discov. 2013 Dec;12(12):931-47
pubmed: 24287781
Immunity. 2013 Dec 12;39(6):1043-56
pubmed: 24315998
Anticancer Res. 2013 Dec;33(12):5433-44
pubmed: 24324079
Trends Cell Biol. 2014 May;24(5):313-20
pubmed: 24361092
Blood. 2014 Jun 12;123(24):3750-9
pubmed: 24782509
Sci Rep. 2014 Jun 05;4:5189
pubmed: 24898534
Immunity. 2014 Jul 17;41(1):75-88
pubmed: 25001241
Nat Immunol. 2014 Sep;15(9):884-93
pubmed: 25029552
Nature. 2014 Sep 25;513(7519):559-63
pubmed: 25043024
Curr Opin Clin Nutr Metab Care. 2014 Nov;17(6):509-14
pubmed: 25111867
Front Immunol. 2014 Jul 28;5:358
pubmed: 25120544
Hum Gene Ther Methods. 2014 Oct;25(5):277-87
pubmed: 25143008
Nat Immunol. 2014 Oct;15(10):904-5
pubmed: 25232813
Front Pharmacol. 2014 Oct 28;5:235
pubmed: 25389405
J Clin Invest. 2015 Jan;125(1):194-207
pubmed: 25437876
Cancer Res. 2014 Dec 15;74(24):7168-74
pubmed: 25477332
Front Pharmacol. 2014 Nov 27;5:254
pubmed: 25505885
Cytotherapy. 2015 Apr;17(4):487-95
pubmed: 25573334
Trends Immunol. 2015 Feb;36(2):71-80
pubmed: 25601541
Cancer Gene Ther. 2015 Mar;22(2):72-8
pubmed: 25613483
Nat Cell Biol. 2015 Apr;17(4):351-9
pubmed: 25774832
Immunity. 2015 Mar 17;42(3):406-17
pubmed: 25786173
Science. 2015 Apr 3;348(6230):74-80
pubmed: 25838376
Cell. 2015 Apr 9;161(2):205-14
pubmed: 25860605
World J Gastrointest Oncol. 2015 Apr 15;7(4):17-29
pubmed: 25897346
Cell. 2015 May 7;161(4):750-61
pubmed: 25957683
Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673):null
pubmed: 26056367
PLoS Biol. 2015 Jul 16;13(7):e1002202
pubmed: 26181372
Mol Immunol. 2015 Dec;68(2 Pt C):507-12
pubmed: 26277274
Cell. 2015 Sep 10;162(6):1229-41
pubmed: 26321679
Cell. 2015 Sep 10;162(6):1217-28
pubmed: 26321681
Cell. 2015 Sep 10;162(6):1242-56
pubmed: 26359984
Science. 2015 Oct 16;350(6258):aab4077
pubmed: 26405231
J Biomed Sci. 2015 Oct 15;22:85
pubmed: 26471060
Nat Rev Clin Oncol. 2016 Jan;13(1):25-40
pubmed: 26525683
Mol Cell. 2015 Nov 19;60(4):514-23
pubmed: 26590711
Cell Metab. 2016 Jan 12;23(1):63-76
pubmed: 26674251
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
J Natl Cancer Inst. 2016 Jan 27;108(7):null
pubmed: 26819347
Immunity. 2016 Feb 16;44(2):380-90
pubmed: 26885860
Nat Rev Immunol. 2016 Mar;16(3):177-92
pubmed: 26922909
EBioMedicine. 2016 Jan 16;4:50-61
pubmed: 26981571
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4777-82
pubmed: 27078105
Oncogene. 2016 Sep 22;35(38):4957-72
pubmed: 27109103
Free Radic Biol Med. 2016 Nov;100:175-181
pubmed: 27117029
Bio Protoc. 2016 Feb 5;6(3):null
pubmed: 27158639
Cell. 2016 Jun 30;166(1):63-76
pubmed: 27293185
Immunity. 2016 Jun 21;44(6):1337-49
pubmed: 27317260
Mol Ther Oncolytics. 2016 Jun 15;3:16015
pubmed: 27347557
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Nat Rev Cancer. 2016 Oct;16(10):619-34
pubmed: 27492215
Cold Spring Harb Mol Case Stud. 2016 Jul;2(4):a000893
pubmed: 27551682
Nat Chem Biol. 2016 Nov;12(11):937-943
pubmed: 27618187
Nature. 2016 Sep 22;537(7621):539-543
pubmed: 27626381
Immunity. 2016 Sep 20;45(3):540-554
pubmed: 27637146
Cell. 2016 Oct 20;167(3):829-842.e13
pubmed: 27745970
Nucleosides Nucleotides Nucleic Acids. 2017 Jan 2;36(1):7-30
pubmed: 27759477
Nature. 2016 Dec 8;540(7632):236-241
pubmed: 27798602
Nat Commun. 2016 Nov 30;7:13683
pubmed: 27901044
Carcinogenesis. 2017 Feb 1;38(2):119-133
pubmed: 27993896
Sci Rep. 2017 Jan 03;7:39762
pubmed: 28045083
Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):580-585
pubmed: 28049847
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E761-E770
pubmed: 28096382
Sci Rep. 2017 Jan 20;7:39833
pubmed: 28106050
J Clin Invest. 2017 Mar 1;127(3):929-941
pubmed: 28165340
Arch Ophthalmol. 1989 Aug;107(8):1113
pubmed: 2818729
Cell. 2017 Feb 9;168(4):724-740
pubmed: 28187291
J Immunol. 2017 Apr 15;198(8):3069-3080
pubmed: 28258191
Immunol Rev. 2017 Mar;276(1):121-144
pubmed: 28258700
Mol Ther Methods Clin Dev. 2016 Dec 31;4:92-101
pubmed: 28344995
Cytokine Growth Factor Rev. 2017 Jun;35:63-70
pubmed: 28363691
Cell. 2017 Apr 06;169(2):258-272.e17
pubmed: 28388410
Cell Metab. 2017 Jun 6;25(6):1282-1293.e7
pubmed: 28416194
Immunity. 2017 Apr 18;46(4):675-689
pubmed: 28423341
Curr Opin Immunol. 2017 Jun;46:45-52
pubmed: 28460345
Cell. 2017 May 4;169(4):570-586
pubmed: 28475890
Nat Rev Cancer. 2017 Aug;17(8):457-474
pubmed: 28706266
Elife. 2017 Aug 15;6:
pubmed: 28826492
Elife. 2017 Sep 13;6:
pubmed: 28901286
Cell. 2017 Oct 5;171(2):358-371.e9
pubmed: 28985563
Nature. 2017 Nov 2;551(7678):115-118
pubmed: 29045397
J Intern Med. 2018 Feb;283(2):110-120
pubmed: 29071761
Trends Cancer. 2017 Nov;3(11):797-808
pubmed: 29120755
J Immunol. 2018 Jan 15;200(2):400-407
pubmed: 29311381
Cell Immunol. 1985 Oct 15;95(2):380-91
pubmed: 2931183
Eur J Appl Physiol. 2018 Apr;118(4):691-728
pubmed: 29322250
Cell Death Dis. 2018 Feb 15;9(3):282
pubmed: 29449531
Curr Opin Biotechnol. 2018 Oct;53:164-181
pubmed: 29462761
Immunity. 2018 Feb 20;48(2):214-226
pubmed: 29466754
Science. 2018 Mar 23;359(6382):1355-1360
pubmed: 29567706
Cell Metab. 2018 Apr 3;27(4):757-785
pubmed: 29617642
Cell. 2018 May 31;173(6):1426-1438.e11
pubmed: 29706540
Front Oncol. 2018 Apr 23;8:120
pubmed: 29740537
Front Immunol. 2018 May 16;9:1075
pubmed: 29868027
Front Pharmacol. 2018 Jun 06;9:606
pubmed: 29928232
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6546-E6555
pubmed: 29941600
Cell Metab. 2018 Jul 3;28(1):3-4
pubmed: 29972796
Nat Immunol. 2018 Aug;19(8):838-848
pubmed: 29988091
Nat Biotechnol. 2018 Sep;36(8):758-764
pubmed: 30010674
Cancer Immunol Res. 2018 Nov;6(11):1375-1387
pubmed: 30143538
Elife. 2018 Sep 10;7:
pubmed: 30198844
Cancer Sci. 2018 Dec;109(12):3737-3750
pubmed: 30302856
Nature. 2018 Oct;562(7727):423-428
pubmed: 30305738
Cell. 2018 Dec 13;175(7):1780-1795.e19
pubmed: 30392958
Nat Immunol. 2018 Dec;19(12):1319-1329
pubmed: 30397348
Nature. 2018 Nov;563(7732):569-573
pubmed: 30429607
Int J Mol Sci. 2018 Dec 02;19(12):null
pubmed: 30513816
Cancer Metab. 2018 Dec 12;6:19
pubmed: 30559963
Sci Adv. 2019 Jan 02;5(1):eaau7314
pubmed: 30613774
Science. 2019 Jan 11;363(6423):
pubmed: 30630899
N Engl J Med. 1987 Mar 5;316(10):589-96
pubmed: 3807953
Lancet. 1972 Nov 18;2(7786):1067-9
pubmed: 4117384
Int Rev Cytol. 1978;54:109-60
pubmed: 42630
Biochem Soc Trans. 1982 Apr;10(2):78-9
pubmed: 6121735
J Immunol. 1984 Jul;133(1):52-8
pubmed: 6609994
Annu Rev Med. 1995;46:235-47
pubmed: 7598460
J Clin Invest. 1997 Dec 1;100(11):2849-57
pubmed: 9389751
Adv Enzymol Relat Areas Mol Biol. 1998;72:87-144
pubmed: 9559052
Cell Mol Life Sci. 1998 Mar;54(3):205-22
pubmed: 9575335
Nat Med. 1998 Dec;4(12):1371-6
pubmed: 9846573