Elevated NLR May Be a Feature of Pediatric Brain Cancer Patients.
LMR
NLR
lymphocytes
neutrophils
pediatric brain cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
02
2019
accepted:
11
04
2019
entrez:
23
5
2019
pubmed:
23
5
2019
medline:
23
5
2019
Statut:
epublish
Résumé
Pediatric brain tumors are the most common solid tumor type and the leading cause of cancer-related death in children. The immune system plays an important role in cancer pathogenesis and in the response to immunotherapy treatments. T lymphocytes are key elements for the response of the immune system to cancer cells and have been associated with prognosis of different cancers. Neutrophils on the other hand, which secrete pro-angiogenic and anti-apoptotic factors, enhance the ability of tumor cells to grow and develop into metastases. We conducted a retrospective study of 120 pediatric brain cancer patients and 171 elective pediatric patients hospitalized in Dana Children's Hospital and Sheba Medical Center. Data on age, sex, treatment, lymphocyte, neutrophil, and monocyte count were collected from routinely performed preoperative blood tests. Neutrophil-to-lymphocyte ratio (NLR), and the lymphocyte-to-monocyte ratio (LMR) were calculated and significance was determined by paired
Identifiants
pubmed: 31114757
doi: 10.3389/fonc.2019.00327
pmc: PMC6502986
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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