Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella.
Animals
Antiviral Agents
/ chemistry
Glycosides
/ chemistry
Ilex
/ chemistry
Lipopolysaccharides
/ antagonists & inhibitors
Macrophages
/ drug effects
Mice
Microbial Sensitivity Tests
Molecular Conformation
Nitric Oxide
/ antagonists & inhibitors
Plant Roots
/ chemistry
RAW 264.7 Cells
Respiratory Syncytial Viruses
/ drug effects
Triterpenes
/ chemistry
Aquifoliaceae
Ilex asprella
cytotoxicity
disulfated triterpenoid glycoside
phytochemistry
triterpenoid glycoside
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
15
04
2019
accepted:
20
05
2019
pubmed:
23
5
2019
medline:
20
8
2019
entrez:
23
5
2019
Statut:
ppublish
Résumé
Asprellosides A-K, nine new ursane-type triterpenoid glycosides (1-9), and two new oleanane-type triterpenoid glycosides (10 and 11), including six rare sulfated triterpenoid glycosides, were isolated from the roots of Ilex asprella. Their structures were determined on the basis of comprehensive spectroscopic analysis and chemical methods. Among these compounds, asprelloside B (2) and asprelloside C (3) are the first examples of triterpenoid glycosides bearing a rare 3,4-O-disulfo-xylopyranosyl residue. All the saponins isolated showed no significant effects against respiratory syncytial virus (RSV) and lipopolysaccharide-induced nitric oxide production in Raw264.7 macrophages.
Identifiants
pubmed: 31115136
doi: 10.1002/cbdv.201900202
doi:
Substances chimiques
Antiviral Agents
0
Glycosides
0
Lipopolysaccharides
0
Triterpenes
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Pagination
e1900202Subventions
Organisme : National Key R&D Program of China
ID : 2017YFC1703800
Organisme : National Natural Science Foundation of China
ID : 81630095
Organisme : National Natural Science Foundation of China
ID : 81803379
Organisme : National Natural Science Foundation of China
ID : 81502939
Organisme : Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
ID : 2017BT01Y03
Organisme : Science and Technology Program of Guangzhou China
ID : 201604046022
Organisme : Fundamental Research Funds for the Central Universities
ID : 21617475
Organisme : Macao Science and Technology Development Fund
ID : FDCT/014/2017/A1
Informations de copyright
© 2019 Wiley-VHCA AG, Zurich, Switzerland.