Neurocognitive Deficits in a Cohort With Class 2 and Class 3 Obesity: Contributions of Type 2 Diabetes and Other Comorbidities.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
12
12
2018
accepted:
02
04
2019
pubmed:
23
5
2019
medline:
15
4
2020
entrez:
23
5
2019
Statut:
ppublish
Résumé
This study examined the relationship between specific metabolic and vascular risk factors and cognition in adults with severe obesity. A total of 129 adults (with BMI ≥ 35 kg/m Diabetes was associated with deficits in overall cognitive performance and with deficits in the executive processing speed and verbal fluency domains. Hemoglobin A1c was inversely related to overall cognitive performance and deficits in the attention domain. Participants using continuous positive airway pressure to treat OSA had stronger learning and memory performance, whereas OSA was associated with reduced total learning. Elevated BMI together with diabetes diagnosis was associated with reduced verbal fluency and greater variability in sustained attention. Obesity-associated comorbidities most notably appeared to have a greater relative influence on cognitive performance than BMI itself in adults with severe obesity. This likely reflects the fact that a very elevated BMI was ubiquitous and thereby probably exerted a similar influence among all adults in the cohort. Accordingly, in the context of severe obesity, diabetes and other comorbidities may have greater sensitivity to cognitive deficits than BMI alone.
Identifiants
pubmed: 31116012
doi: 10.1002/oby.22508
pmc: PMC6666310
mid: NIHMS1526480
doi:
Banques de données
ClinicalTrials.gov
['NCT02137070']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1099-1106Subventions
Organisme : NIAAA NIH HHS
ID : K01 AA025306
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061065
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099334
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA022618
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA020797
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA025877
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001429
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH074368
Pays : United States
Informations de copyright
© 2019 The Obesity Society.
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