New positive patch test reactions on day 7-The additional value of the day 7 patch test reading.
D7 reading
allergic contact dermatitis
epidemiology
new positive D7 reactions
patch testing
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
29
03
2019
revised:
15
05
2019
accepted:
21
05
2019
pubmed:
23
5
2019
medline:
13
2
2020
entrez:
23
5
2019
Statut:
ppublish
Résumé
Not performing a day (D) 7 patch test reading might result in positive patch test reactions being missed. To investigate the added value of the D7 patch test reading for individual allergens, and to identify patient characteristics and allergen groups associated with new positive D7 reactions. Data from patients patch tested between 2008 and 2018 with the extended European baseline series were analysed. Patch test readings were performed on D3 and D7. Positive reactions were categorized into positive on D3 or new positive on D7. A total of 3292 patients were consecutively patch tested with at least 43 allergens of the TRUE Test panels 1 and 2 supplemented with investigator-loaded allergens. In total, 447 (13.6%) patients showed new positive D7 reactions. In univariable regression analysis, age between 18 and 30 years showed a negative association with new positive D7 reactions. Significantly more D7 positive reactions were seen for topicals (odds ratio [OR] 2.60, 95% confidence interval [CI]: 1.92-3.51) and corticosteroids (OR 1.87, 95%CI: 1.09-3.21). No associations were found between sex, atopic dermatitis and occupational dermatitis and a new positive D7 reaction. A D7 reading to identify new positive patch test reactions is of added value, especially for topicals and corticosteroids.
Sections du résumé
BACKGROUND
BACKGROUND
Not performing a day (D) 7 patch test reading might result in positive patch test reactions being missed.
OBJECTIVES
OBJECTIVE
To investigate the added value of the D7 patch test reading for individual allergens, and to identify patient characteristics and allergen groups associated with new positive D7 reactions.
METHODS
METHODS
Data from patients patch tested between 2008 and 2018 with the extended European baseline series were analysed. Patch test readings were performed on D3 and D7. Positive reactions were categorized into positive on D3 or new positive on D7.
RESULTS
RESULTS
A total of 3292 patients were consecutively patch tested with at least 43 allergens of the TRUE Test panels 1 and 2 supplemented with investigator-loaded allergens. In total, 447 (13.6%) patients showed new positive D7 reactions. In univariable regression analysis, age between 18 and 30 years showed a negative association with new positive D7 reactions. Significantly more D7 positive reactions were seen for topicals (odds ratio [OR] 2.60, 95% confidence interval [CI]: 1.92-3.51) and corticosteroids (OR 1.87, 95%CI: 1.09-3.21). No associations were found between sex, atopic dermatitis and occupational dermatitis and a new positive D7 reaction.
CONCLUSION
CONCLUSIONS
A D7 reading to identify new positive patch test reactions is of added value, especially for topicals and corticosteroids.
Identifiants
pubmed: 31116435
doi: 10.1111/cod.13322
pmc: PMC6771944
doi:
Substances chimiques
Allergens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
280-287Informations de copyright
© 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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