Chemotherapy-Induced Extracellular Vesicle miRNAs Promote Breast Cancer Stemness by Targeting
Animals
Breast Neoplasms
/ drug therapy
Cell Line, Tumor
Docetaxel
/ pharmacology
Doxorubicin
/ pharmacology
Drug Resistance, Neoplasm
Extracellular Vesicles
/ drug effects
Female
Homeodomain Proteins
/ genetics
Humans
MCF-7 Cells
Mice
Mice, Inbred NOD
Mice, SCID
MicroRNAs
/ genetics
Neoplastic Stem Cells
/ drug effects
Transcription Factors
/ genetics
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
24
12
2018
revised:
04
03
2019
accepted:
17
05
2019
pubmed:
24
5
2019
medline:
9
4
2020
entrez:
24
5
2019
Statut:
ppublish
Résumé
Cancer-secreted, extracellular vesicle (EV)-encapsulated miRNAs enable cancer cells to communicate with each other and with noncancerous cells in tumor pathogenesis and response to therapies. Here, we show that treatment with a sublethal dose of chemotherapeutic agents induces breast cancer cells to secrete EV with the capacity to stimulate a cancer stem-like cell (CSC) phenotype, rendering cancer cells resistance to therapy. Chemotherapy induced breast cancer cells to secrete multiple EV miRNAs, including miR-9-5p, miR-195-5p, and miR-203a-3p, which simultaneously targeted the transcription factor One Cut Homeobox 2 (ONECUT2), leading to induction of CSC traits and expression of stemness-associated genes, including
Identifiants
pubmed: 31118200
pii: 0008-5472.CAN-18-4055
doi: 10.1158/0008-5472.CAN-18-4055
pmc: PMC8972808
mid: NIHMS1771140
doi:
Substances chimiques
Homeodomain Proteins
0
MicroRNAs
0
ONECUT2 protein, human
0
Transcription Factors
0
Docetaxel
15H5577CQD
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3608-3621Subventions
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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