AAV-encoded Ca
Animals
Aptamers, Peptide
/ chemistry
Calcium Channel Blockers
/ chemistry
Calcium Channels, N-Type
/ metabolism
Dependovirus
/ genetics
Ganglia, Spinal
/ metabolism
Genetic Therapy
/ methods
Green Fluorescent Proteins
/ genetics
Intercellular Signaling Peptides and Proteins
/ chemistry
Male
Nerve Tissue Proteins
/ chemistry
Neuralgia
/ therapy
Protein Domains
Rats
Rats, Sprague-Dawley
Journal
Gene therapy
ISSN: 1476-5462
Titre abrégé: Gene Ther
Pays: England
ID NLM: 9421525
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
05
12
2018
accepted:
20
03
2019
revised:
25
02
2019
pubmed:
24
5
2019
medline:
15
1
2020
entrez:
24
5
2019
Statut:
ppublish
Résumé
Transmission of pain signals from primary sensory neurons to secondary neurons of the central nervous system is critically dependent on presynaptic voltage-gated calcium channels. Calcium channel-binding domain 3 (CBD3), derived from the collapsin response mediator protein 2 (CRMP2), is a peptide aptamer that is effective in blocking N-type voltage-gated calcium channel (Ca
Identifiants
pubmed: 31118475
doi: 10.1038/s41434-019-0082-7
pii: 10.1038/s41434-019-0082-7
pmc: PMC6707887
mid: NIHMS1037978
doi:
Substances chimiques
Aptamers, Peptide
0
Cacna1b protein, rat
0
Calcium Channel Blockers
0
Calcium Channels, N-Type
0
Intercellular Signaling Peptides and Proteins
0
Nerve Tissue Proteins
0
collapsin response mediator protein-2
0
Green Fluorescent Proteins
147336-22-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
308-323Subventions
Organisme : RRD VA
ID : I01 RX001940
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042852
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS098772
Pays : United States
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