Alterations of the Gut Microbiota Associated With Promoting Efficacy of Prednisone by Bromofuranone in MRL/lpr Mice.
AI-2/LuxS quorum sensing
MRL/lpr mice
bromofuranone
gut microbiota
prednisone
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
06
2018
accepted:
18
04
2019
entrez:
24
5
2019
pubmed:
24
5
2019
medline:
24
5
2019
Statut:
epublish
Résumé
Gut microbiota played an important role in systemic lupus erythematosus (SLE) and glucocorticoids were prone to cause alterations in gut microbiota. This study addressed the effect of bromofuranone on the treatment of SLE with prednisone, since bromofuranone could regulate gut microbiota by inhibiting the AI-2/LuxS quorum-sensing. Remarkably, bromofuranone did not alleviate lupus but promoted the efficacy of prednisone in the treatment of lupus. The alterations in the gut microbiota, including decreased
Identifiants
pubmed: 31118928
doi: 10.3389/fmicb.2019.00978
pmc: PMC6504707
doi:
Types de publication
Journal Article
Langues
eng
Pagination
978Références
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