Altered expression of ionotropic L-Glutamate receptors in aged sensory neurons of Aplysia californica.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
11
2018
accepted:
08
05
2019
entrez:
24
5
2019
pubmed:
24
5
2019
medline:
30
1
2020
Statut:
epublish
Résumé
The simplified nervous system of Aplysia californica (Aplysia) allows for detailed studies of physiological and molecular changes in small sets of neurons. Sensory neurons of the biting and tail withdrawal reflexes are glutamatergic and show reduced L-Glutamate current density in aged animals, making them a good candidate to study age-related changes in glutamatergic responses. To examine if changes in ionotropic L-Glu receptor (iGluR) transcription underlie reduced physiology, mRNA expression of iGluR was quantified in two sensory neuron clusters of two cohorts of Aplysia at both sexual maturity (~8 months) and advanced age (~12 months). Sensory neuron aging resulted in a significant overall decrease in expression of iGluR subunits in both sensory neuron clusters and cohorts. Although the individual subunits differentially expressed varied between sensory neuron clusters and different cohorts of animals, all differentially expressed subunits were downregulated, with no subunits showing significantly increased expression with age. Overall declines in transcript expression suggest that age-related declines in L-Glu responsiveness in Aplysia sensory neurons could be linked to overall declines in iGluR expression, rather than dysregulation of specific subunits. In both sensory neuron clusters tested the N-methyl-D-aspartate receptor subtype was expressed at significantly greater levels than other iGluR subtypes, suggesting an in vivo role for NMDAR-like receptors in Aplysia sensory neurons.
Identifiants
pubmed: 31120976
doi: 10.1371/journal.pone.0217300
pii: PONE-D-18-32516
pmc: PMC6532900
doi:
Substances chimiques
Protein Subunits
0
RNA, Messenger
0
Receptors, Ionotropic Glutamate
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0217300Subventions
Organisme : NIH HHS
ID : P40 OD010952
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared no competing interests exist.
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